保护的免疫相关性是结核病疫苗研发中的一个转折点。

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2024-10-30 DOI:10.1038/s41541-024-01004-w

Jing Wang, Xiao-Yong Fan, Zhidong Hu

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引用次数: 0

摘要

缺乏有效的保护相关因子（CoPs）阻碍了新型结核病疫苗的合理设计和临床开发。在这篇综述中，我们概述了结核病疫苗研究中潜在的相关保护因子。然后讨论了主要障碍和潜在机遇。根据最近取得的进展，我们有理由相信，正在进行的CoPs鉴定工作的成功将改变结核病疫苗的开发。

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Immune correlates of protection as a game changer in tuberculosis vaccine development.

The absence of validated correlates of protection (CoPs) hampers the rational design and clinical development of new tuberculosis vaccines. In this review, we provide an overview of the potential CoPs in tuberculosis vaccine research. Major hindrances and potential opportunities are then discussed. Based on recent progress, it is reasonable to anticipate that success in the ongoing efforts to identify CoPs would be a game-changer in tuberculosis vaccine development.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.