氯氮平治疗一位七旬老人的帕金森病精神病：噩梦变成了幸福。

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-10-30 DOI:10.1007/s10072-024-07852-7

Janki Makani, Anand Kumar, Ibrahim Hussain, Niraj Kumar, Deepika Joshi

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引用次数: 0

摘要

帕金森病的精神错乱以意识模糊、视幻觉和妄想为特征，是患者和护理人员的噩梦。传统的神经安定剂会加重运动症状，因此需要一种有效的非典型抗精神病药物。目前，Pimavanserin 是唯一获准治疗帕金森病性精神病（PDP）的药物，但它并不容易买到。氯氮平具有良好的抗精神病特性，不会导致运动功能恶化，成本效益高且易于获得，在改善患有精神病的帕金森病患者的生活质量方面超越了所有界限。我们描述了一名老年 PDP 患者对小剂量氯氮平的良好反应。

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Clozapine for Parkinson's disease psychosis in a septuagenarian: a nightmare turned into bliss.

Parkinson's disease psychosis, characterized by confusion, visual hallucinations, and delusions is a nightmare for the patients and caregivers. Classic neuroleptics aggravate the motor symptoms, hence the need for an effective atypical antipsychotic. Currently Pimavanserin is the only approved drug for Parkinson's disease psychosis (PDP), however it is not readily available. Clozapine with its excellent anti psychotic profile, without worsening of motor features, cost effectiveness and easy availability transcends all boundaries in improving the Quality of life in PD patients with psychosis. We describe an elderly patient with PDP with an excellent response to low dose clozapine.

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.