微波消融功率和天线方法对肿瘤播种的影响:体内囊下肿瘤模型研究

IF 4.4 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Hyo Jeong Lee, Chang Hoon Oh, Jin Sil Kim, Jeong Kyong Lee
{"title":"微波消融功率和天线方法对肿瘤播种的影响:体内囊下肿瘤模型研究","authors":"Hyo Jeong Lee, Chang Hoon Oh, Jin Sil Kim, Jeong Kyong Lee","doi":"10.3348/kjr.2024.0602","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of microwave (MW) power and antenna approach methods on extrahepatic tumor seeding and ablation zone size using an ex vivo subcapsular tumor-mimic model.</p><p><strong>Materials and methods: </strong>Forty-one subcapsular tumor mimics were prepared by injecting a mixture of contrast media into bovine liver blocks. Ablation was performed using low- and high-power protocols (75 W and 100 W for 4 and 3 minutes, respectively). The antenna approach was assessed in two directions: parallel and perpendicular to the capsule. CT scans were obtained before and after the ablation to detect contrast leakage on the hepatic surface. The presence of leakage, ablation zone size, and the timing of the first popping sound were compared between the two groups.</p><p><strong>Results: </strong>Five cases of contrast leakage were observed in the low-power group (n = 21) and 17 in the high-power group (n = 20) (23.8% vs. 85.0%, <i>P</i> < 0.001). Contrast leaks were less frequently observed in the low-power protocol compared to the high-power protocol, regardless of the antenna approach (18.2% [2/11] vs. 80.0% [8/10], <i>P</i> = 0.009 for parallel access; 30.0% [3/10] vs. 90.0% [9/10], <i>P</i> = 0.020 for perpendicular access). The timing of the first popping sound was significantly delayed in the low-power group compared to the high-power group (137.7 ± 51.4 s vs. 77.8 ± 31.4 s, <i>P</i> < 0.001). The size of the ablation zone did not differ significantly between the two power groups (<i>P</i> = 0.415). The parallel and perpendicular antenna approaches did not show significant differences in the number of contrast leaks, popping sound timing, or ablation-zone size (<i>P</i> = 0.536, 0.463, and 0.271, respectively).</p><p><strong>Conclusion: </strong>Low-power MW ablation may be superior to a high-power protocol in reducing the risk of tumor seeding in subcapsular tumors, regardless of the antenna approach.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524685/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of Microwave Ablation Power and Antenna Approach on Tumor Seeding: An Ex Vivo Subcapsular Tumor Model Study.\",\"authors\":\"Hyo Jeong Lee, Chang Hoon Oh, Jin Sil Kim, Jeong Kyong Lee\",\"doi\":\"10.3348/kjr.2024.0602\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the effects of microwave (MW) power and antenna approach methods on extrahepatic tumor seeding and ablation zone size using an ex vivo subcapsular tumor-mimic model.</p><p><strong>Materials and methods: </strong>Forty-one subcapsular tumor mimics were prepared by injecting a mixture of contrast media into bovine liver blocks. Ablation was performed using low- and high-power protocols (75 W and 100 W for 4 and 3 minutes, respectively). The antenna approach was assessed in two directions: parallel and perpendicular to the capsule. CT scans were obtained before and after the ablation to detect contrast leakage on the hepatic surface. The presence of leakage, ablation zone size, and the timing of the first popping sound were compared between the two groups.</p><p><strong>Results: </strong>Five cases of contrast leakage were observed in the low-power group (n = 21) and 17 in the high-power group (n = 20) (23.8% vs. 85.0%, <i>P</i> < 0.001). Contrast leaks were less frequently observed in the low-power protocol compared to the high-power protocol, regardless of the antenna approach (18.2% [2/11] vs. 80.0% [8/10], <i>P</i> = 0.009 for parallel access; 30.0% [3/10] vs. 90.0% [9/10], <i>P</i> = 0.020 for perpendicular access). The timing of the first popping sound was significantly delayed in the low-power group compared to the high-power group (137.7 ± 51.4 s vs. 77.8 ± 31.4 s, <i>P</i> < 0.001). The size of the ablation zone did not differ significantly between the two power groups (<i>P</i> = 0.415). The parallel and perpendicular antenna approaches did not show significant differences in the number of contrast leaks, popping sound timing, or ablation-zone size (<i>P</i> = 0.536, 0.463, and 0.271, respectively).</p><p><strong>Conclusion: </strong>Low-power MW ablation may be superior to a high-power protocol in reducing the risk of tumor seeding in subcapsular tumors, regardless of the antenna approach.</p>\",\"PeriodicalId\":17881,\"journal\":{\"name\":\"Korean Journal of Radiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524685/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Korean Journal of Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3348/kjr.2024.0602\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3348/kjr.2024.0602","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

摘要

目的:评估微波功率和天线方法对肝外肿瘤播种和消融区大小的影响:利用体外囊下肿瘤模拟模型,评估微波(MW)功率和天线方法对肝外肿瘤播种和消融区大小的影响:通过向牛肝块注射造影剂混合物制备了 41 个囊下肿瘤模拟物。消融采用低功率和高功率方案(分别为 75 瓦和 100 瓦,4 分钟和 3 分钟)。从两个方向对天线方法进行了评估:平行于囊的方向和垂直于囊的方向。消融前后均进行 CT 扫描,以检测肝表面的造影剂渗漏情况。对两组患者的渗漏情况、消融区大小和首次爆裂声的时间进行比较:结果:低功率组(21 人)观察到 5 例造影剂渗漏,高功率组(20 人)观察到 17 例(23.8% 对 85.0%,P<0.001)。与高功率方案相比,无论采用哪种天线方式,低功率方案都较少观察到对比剂泄漏(平行入路为 18.2% [2/11] vs. 80.0% [8/10],P = 0.009;垂直入路为 30.0% [3/10] vs. 90.0% [9/10],P = 0.020)。与高功率组相比,低功率组发出第一声爆裂声的时间明显延迟(137.7 ± 51.4 秒 vs 77.8 ± 31.4 秒,P < 0.001)。两组功率的消融区大小差异不大(P = 0.415)。平行和垂直天线方法在造影剂泄漏数量、爆音时间或消融区大小方面没有显著差异(P = 0.536、0.463 和 0.271):结论:在降低囊下肿瘤播种风险方面,低功率兆瓦消融可能优于高功率方案,与天线方式无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Microwave Ablation Power and Antenna Approach on Tumor Seeding: An Ex Vivo Subcapsular Tumor Model Study.

Objective: To evaluate the effects of microwave (MW) power and antenna approach methods on extrahepatic tumor seeding and ablation zone size using an ex vivo subcapsular tumor-mimic model.

Materials and methods: Forty-one subcapsular tumor mimics were prepared by injecting a mixture of contrast media into bovine liver blocks. Ablation was performed using low- and high-power protocols (75 W and 100 W for 4 and 3 minutes, respectively). The antenna approach was assessed in two directions: parallel and perpendicular to the capsule. CT scans were obtained before and after the ablation to detect contrast leakage on the hepatic surface. The presence of leakage, ablation zone size, and the timing of the first popping sound were compared between the two groups.

Results: Five cases of contrast leakage were observed in the low-power group (n = 21) and 17 in the high-power group (n = 20) (23.8% vs. 85.0%, P < 0.001). Contrast leaks were less frequently observed in the low-power protocol compared to the high-power protocol, regardless of the antenna approach (18.2% [2/11] vs. 80.0% [8/10], P = 0.009 for parallel access; 30.0% [3/10] vs. 90.0% [9/10], P = 0.020 for perpendicular access). The timing of the first popping sound was significantly delayed in the low-power group compared to the high-power group (137.7 ± 51.4 s vs. 77.8 ± 31.4 s, P < 0.001). The size of the ablation zone did not differ significantly between the two power groups (P = 0.415). The parallel and perpendicular antenna approaches did not show significant differences in the number of contrast leaks, popping sound timing, or ablation-zone size (P = 0.536, 0.463, and 0.271, respectively).

Conclusion: Low-power MW ablation may be superior to a high-power protocol in reducing the risk of tumor seeding in subcapsular tumors, regardless of the antenna approach.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Korean Journal of Radiology
Korean Journal of Radiology 医学-核医学
CiteScore
10.60
自引率
12.50%
发文量
141
审稿时长
1.3 months
期刊介绍: The inaugural issue of the Korean J Radiol came out in March 2000. Our journal aims to produce and propagate knowledge on radiologic imaging and related sciences. A unique feature of the articles published in the Journal will be their reflection of global trends in radiology combined with an East-Asian perspective. Geographic differences in disease prevalence will be reflected in the contents of papers, and this will serve to enrich our body of knowledge. World''s outstanding radiologists from many countries are serving as editorial board of our journal.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信