一种用于 PDT/PTT 协同治疗细菌感染的 BODIPY 衍生物。

IF 3.9 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of photochemistry and photobiology. B, Biology Pub Date : 2024-10-28 DOI:10.1016/j.jphotobiol.2024.113049

Qijia Sun , Aoqing Jia , Min Zhao , Ke Wang , Tingting Sun , Zhigang Xie

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引用次数: 0

摘要

光疗抗菌剂，包括光动力抗菌剂和光热抗菌剂，因其广谱抗菌活性和低抗药性风险而被认为是抗生素策略的有效替代品。在这里，一种含有三苯胺基团的 4,4-二氟-4-硼-3a,4a-二氮杂-s-茚并（BODIPY）衍生物与 Pluronic F-127 （F-127）共同组装成纳米颗粒（BICF NPs）。BICF NPs 具有出色的光动力和光热特性，已被证明能有效抑制和破坏细菌生物膜，从而促进皮下脓肿的愈合。这项工作为抗生素替代疗法提供了一条新途径。

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A BODIPY derivative for PDT/PTT synergistic treatment of bacterial infections

Phototherapeutic antimicrobials, including photodynamic and photothermal antimicrobials, are considered effective alternatives for antibiotic strategy due to their broad-spectrum antibacterial activity and low risk of resistance. Here, a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivative containing triphenylamine groups was co-assembled with Pluronic F-127 (F-127) to form nanoparticles (BICF NPs). BICF NPs have excellent photodynamic and photothermal properties and are demonstrated to be effective in inhibiting and disrupting bacterial biofilms, thereby promoting the healing of subcutaneous abscesses. This work provides a new avenue for antibiotic replacement therapy.

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来源期刊

Journal of photochemistry and photobiology. B, Biology 生物-生化与分子生物学

CiteScore

12.10

自引率

1.90%

发文量

161

审稿时长

37 days

期刊介绍： The Journal of Photochemistry and Photobiology B: Biology provides a forum for the publication of papers relating to the various aspects of photobiology, as well as a means for communication in this multidisciplinary field. The scope includes: - Bioluminescence - Chronobiology - DNA repair - Environmental photobiology - Nanotechnology in photobiology - Photocarcinogenesis - Photochemistry of biomolecules - Photodynamic therapy - Photomedicine - Photomorphogenesis - Photomovement - Photoreception - Photosensitization - Photosynthesis - Phototechnology - Spectroscopy of biological systems - UV and visible radiation effects and vision.