终生有自杀未遂史的人及其与炎症、抑郁症状严重程度和童年虐待的关系。

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Journal of Nervous and Mental Disease Pub Date : 2024-11-01 Epub Date: 2024-10-13 DOI:10.1097/NMD.0000000000001805
Gisele de Souza Teixeira Bellinello, Mariana Urbano, Heber Odebrecht Vargas, Waldiceu Verri, Ana Carolina Rossaneis, Sandra Odebrecht Vargas Nunes
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引用次数: 0

摘要

摘要:终生自杀未遂史与炎症机制、抑郁症状严重程度和童年创伤有关。这项横断面研究共招募了 54 名自杀未遂者和 154 名非自杀未遂者。研究人员通过问卷调查、结构化临床访谈、量表、人体测量和实验室生物标志物对所有人进行了评估。有自杀未遂史的人的可溶性肿瘤坏死因子受体1与抑郁症状的严重程度(p = 0.013)、白细胞介素-1受体拮抗剂与抑郁症状的严重程度(p = 0.04)、旷工与童年身体虐待(p = 0.012)呈显著正相关。与非自杀企图者相比,自杀企图者也经历了更多的童年创伤(性虐待、身体虐待、情感虐待、情感忽视和身体忽视)。自杀未遂者的 IL-4 水平明显低于未自杀者。重性情感障碍患者终生企图自杀与童年创伤以及促炎和抗炎细胞因子有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Individuals Who Had a Lifetime History of Suicide Attempts and Their Relationships With Inflammation, Severity of Depressive Symptoms, and Childhood Maltreatments.

Abstract: Lifetime history of suicide attempts is associated with inflammatory mechanisms, severity of depressive symptoms, and childhood trauma. This cross-sectional study enrolled 54 suicide attempters and 154 nonsuicide attempters. All individuals were assessed through a questionnaire, a structured clinical interview, scales, anthropometric measures, and laboratory biomarkers. Individuals with a history of lifetime suicide attempts showed significant positive correlations regarding soluble tumor necrosis factor receptor 1 and severity of depressive symptoms (p = 0.013), interleukin-1 receptor antagonist and severity of depressive symptoms (p = 0.04), and absenteeism from work and childhood physical abuse (p = 0.012). Suicide attempters also experienced more childhood trauma (sexual abuse, physical abuse, emotional abuse, emotional neglect, and physical neglect) compared with nonsuicide attempters. IL-4 levels were significantly lower in individuals who attempted suicide than in nonsuicidal individuals. Lifetime suicide attempts in major affective disorders were associated with childhood trauma and proinflammatory and anti-inflammatory cytokines.

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来源期刊
CiteScore
2.90
自引率
5.30%
发文量
233
审稿时长
3-8 weeks
期刊介绍: The Journal of Nervous and Mental Disease publishes peer-reviewed articles containing new data or ways of reorganizing established knowledge relevant to understanding and modifying human behavior, especially that defined as impaired or diseased, and the context, applications and effects of that knowledge. Our policy is summarized by the slogan, "Behavioral science for clinical practice." We consider articles that include at least one behavioral variable, clear definition of study populations, and replicable research designs. Authors should use the active voice and first person whenever possible.
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