Shizhe Zhu, Qinglei Wang, Chaojie Kan, Ayan Geng, Youxin Sui, Ren Zhuang, Yi Zhu, Tong Wang, Lan Zhu, Chuan Guo
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Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study.
Background: The n-back task is a widely used paradigm to assess working memory and is commonly applied in research on age-related cognitive decline. However, studies utilizing functional near-infrared spectroscopy (fNIRS) to explore this area are limited.
Objective: This study aims to investigate age-related differences in brain activation during the n-back task using fNIRS.
Methods: fNIRS data were collected from 18 elderly and 19 young participants while performing different n-back tasks. Brain activation patterns and peripheral performance were compared between the two groups.
Results: Significant differences in brain activation patterns were observed between elderly and young participants. Under the 3-back condition, the older group exhibited reduced activation in brain regions adjacent to prefrontal cognitive areas compared to the younger group. Additionally, the older group's performance plateaued at the 2-back level, along with a decline in prefrontal activation.
Conclusion: These findings may suggest potential markers for cognitive decline, providing a new target for future screening.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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