美国 9-10 岁儿童细颗粒物成分、来源与认知结果之间的关系。

IF 10.1 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Environmental Health Perspectives Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI:10.1289/EHP14418
Kirthana Sukumaran, Katherine L Botternhorn, Joel Schwartz, Jim Gauderman, Carlos Cardenas-Iniguez, Rob McConnell, Daniel A Hackman, Kiros Berhane, Hedyeh Ahmadi, Shermaine Abad, Rima Habre, Megan M Herting
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引用次数: 0

摘要

背景:新近的文献表明,空气污染中的细颗粒物[空气动力学直径≤2.5μm(PM2.5)]及其成分与各种神经发育结果有关。然而,很少有研究对不同来源的 PM2.5 混合物成分与儿童认知结果的关系进行评估:这项横断面研究调查了美国各地 PM2.5 成分混合物的环境浓度与 9 至 10 岁儿童神经认知能力的关系,并探讨了这些关联的潜在特定来源效应:利用时空混合模型,根据青少年大脑认知发展(ABCD)研究中儿童参与者的居住地址估算出 PM2.5 中 15 种化学成分的年浓度。一般认知能力、执行功能和学习/记忆力评分来自美国国立卫生研究院工具箱。我们采用正矩阵因式分解法,根据 15 个成分确定了 PM2.5 的六个主要来源,包括地壳、硫酸铵、生物质燃烧、交通、硝酸铵和工业/剩余燃料燃烧。然后,我们利用加权量化总和(WQS)和线性回归模型研究了PM2.5成分混合物、其潜在来源与儿童认知分数之间的关系:结果:混合物模型揭示了累积暴露量与所有三个结果领域认知能力下降之间的关系,包括硝酸铵、硅和钙所产生的有害影响的共同重叠。利用已确定的六种暴露源,确定了硝酸铵与学习和记忆、交通与执行功能以及地壳和工业混合物与一般认知能力之间的负相关。交通与一般能力以及生物质燃烧与执行功能之间也存在意想不到的正相关关系:讨论:这项研究表明,室外 PM2.5 暴露与儿童认知能力之间存在微妙的联系,包括与单个化学品以及这些暴露的特定来源有关的认知能力的重要差异。https://doi.org/10.1289/EHP14418。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between Fine Particulate Matter Components, Their Sources, and Cognitive Outcomes in Children Ages 9-10 Years Old from the United States.

Background: Emerging literature suggests that fine particulate matter [with aerodynamic diameter 2.5μm (PM2.5)] air pollution and its components are linked to various neurodevelopmental outcomes. However, few studies have evaluated how PM2.5 component mixtures from distinct sources relate to cognitive outcomes in children.

Objectives: This cross-sectional study investigated how ambient concentrations of PM2.5 component mixtures relate to neurocognitive performance in 9- to 10-year-old children, as well as explored potential source-specific effects of these associations, across the US.

Methods: Using spatiotemporal hybrid models, annual concentrations of 15 chemical components of PM2.5 were estimated based on the residential address of child participants from the Adolescent Brain Cognitive Development (ABCD) Study. General cognitive ability, executive function, and learning/memory scores were derived from the NIH Toolbox. We applied positive matrix factorization to identify six major PM2.5 sources based on the 15 components, which included crustal, ammonium sulfate, biomass burning, traffic, ammonium nitrate, and industrial/residual fuel burning. We then utilized weighted quantile sum (WQS) and linear regression models to investigate associations between PM2.5 components' mixture, their potential sources, and children's cognitive scores.

Results: Mixture modeling revealed associations between cumulative exposure and worse cognitive performance across all three outcome domains, including shared overlap in detrimental effects driven by ammonium nitrates, silicon, and calcium. Using the identified six sources of exposure, source-specific negative associations were identified between ammonium nitrates and learning & memory, traffic and executive function, and crustal and industrial mixtures and general cognitive ability. Unexpected positive associations were also seen between traffic and general ability as well as biomass burning and executive function.

Discussion: This work suggests nuanced associations between outdoor PM2.5 exposure and childhood cognitive performance, including important differences in cognition related both to individual chemicals as well as to specific sources of these exposures. https://doi.org/10.1289/EHP14418.

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来源期刊
Environmental Health Perspectives
Environmental Health Perspectives 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
14.40
自引率
2.90%
发文量
388
审稿时长
6 months
期刊介绍: Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.
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