研究 elegans 的同源染色体基因近 40 年。

IF 3.7 2区生物学 Q1 DEVELOPMENTAL BIOLOGY

Development Pub Date : 2024-11-01 Epub Date: 2024-10-30 DOI:10.1242/dev.204328

Paschalis Kratsios, Oliver Hobert

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引用次数: 0

摘要

同源染色体基因是转录因子编码基因中保守性最强的基因家族之一。继在果蝇中发现同源框基因之后，同源框基因又以迅雷不及掩耳之势登上了秀丽隐杆线虫的舞台。1988 年至 1990 年间，也就是在苍蝇和脊椎动物中首次发现同源基因后的短短几年间，定位克隆和基于序列的搜索显示，秀丽隐杆线虫含有 HOX 簇基因，这显然是一个令人惊讶的发现，因为秀丽隐杆线虫的身体结构简单且不分节，而且所有主要亚家族（如 LIM、POU 等）中还有许多其他非簇同源基因。不到 40 年后，我们对同源染色体蛋白在 elegans 中的表达和功能有了非常深入的了解，揭示了它们在神经系统发育中的普遍作用。在本《聚焦》中，我们将从历史的角度对 elegans 同源体领域进行非全面的介绍，并讨论开放性问题和未来发展方向。

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Almost 40 years of studying homeobox genes in C. elegans.

Homeobox genes are among the most deeply conserved families of transcription factor-encoding genes. Following their discovery in Drosophila, homeobox genes arrived on the Caenorhabditis elegans stage with a vengeance. Between 1988 and 1990, just a few years after their initial discovery in flies and vertebrates, positional cloning and sequence-based searches showed that C. elegans contains HOX cluster genes, an apparent surprise given the simplicity and non-segmented body plan of the nematode, as well as many other non-clustered homeobox genes of all major subfamilies (e.g. LIM, POU, etc.). Not quite 40 years later, we have an exceptionally deep understanding of homeodomain protein expression and function in C. elegans, revealing their prevalent role in nervous system development. In this Spotlight, we provide a historical perspective and a non-comprehensive journey through the C. elegans homeobox field and discuss open questions and future directions.

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来源期刊

Development 生物-发育生物学

CiteScore

6.70

自引率

4.30%

发文量

433

审稿时长

3 months

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