原始牙源性肿瘤与牙源性囊肿并存的组织病理学特征：全球首例报告病例，并提出 "最新诊断标准"。

IF 2.4 3区医学 Q2 PATHOLOGY

Diagnostic Pathology Pub Date : 2024-10-29 DOI:10.1186/s13000-024-01560-8

Dhara Dwivedi, Nitin Prabhakar, Monal Yuwanati, Gunjan S Aswal, Renu Rawat

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引用次数: 0

摘要

背景：原始牙源性肿瘤（POT）是一种较新描述的良性牙源性肿瘤，迄今为止登记在册的病例极少。我们报告了第一例来自撒哈拉以南非洲的原始牙源性肿瘤（POT），该病例具有独特的临床病理特征；这也是第一例报告原始牙源性肿瘤作为混合性牙源性病变（HOL）存在的病例，并对文献进行了相关回顾：这是一名 17 岁的患者，因下颌骨后部肿物生长缓慢、无痛而就诊。影像学检查显示，患者的下颌后部肿物轮廓清晰、单球形、膨胀性、溶解性病变，内部有钙化灶，周围有一颗撞击性的 36 号牙，这表明患者患上了钙化性牙源性囊肿。切口活检显示存在 POT。肿瘤连同受累牙齿一起切除：结论：POT 主要是一种非侵袭性肿瘤，多发于儿童群体。因此，临床医生必须了解该肿瘤的所有方面，以便做出正确诊断，避免过度治疗或治疗不当。

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Histopathological spectrum of primordial odontogenic tumor with co-existing dentigerous cyst: 1^st reported case of the world with a proposed 'updated diagnostic criteria'.

Background: POT is a relatively newly described benign odontogenic tumor with very few cases registered to date. We present the 1st case of Primordial odontogenic tumor (POT) from Sub-Saharan Africa with unique clinicopathological features; also, this is the first case to report POT's existence as a Hybrid Odontogenic lesion (HOL), with a pertinent review of the literature.

Case presentation: This was a 17-year-old patient who presented with slow-growing, painless posterior mandibular swelling. The imaging revealed a well-defined, unilocular, expansile, lytic lesion with internal calcific foci surrounding an impacted #36, indicating a calcifying odontogenic cyst. The incisional biopsy revealed the presence of POT. The tumor was excised along with the involved tooth.

Conclusion: POT is predominantly a non-aggressive and mostly affects the pediatric population. Hence, clinicians must be updated on all the aspects of this tumor to diagnose it appropriately and avoid any undue over-or under-treatment.

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).