败血症相关脑病病理过程中突触可塑性的生物学变化

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Lin Yang, Jin Li, Fuhong Liu, Xin Chai, Zongping Fang, Xijing Zhang
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引用次数: 0

摘要

败血症相关脑病(SAE)是败血症导致的一种认知和心理障碍,发生时没有任何中枢神经系统感染或脑部结构损伤。患者出院后仍可能出现长期认知障碍和精神障碍。然而,其潜在机制仍不清楚。由于认知功能和精神疾病与突触可塑性密切相关,因此推测突触可塑性的改变在 SAE 的病理过程中起着至关重要的作用。在此,我们系统地描述了 SAE 的发病机制,其主要驱动因素是神经胶质细胞的激活和随后炎症介质的释放。此外,我们还阐明了在 SAE 过程中发生的突触可塑性改变,并全面讨论了神经胶质细胞和炎症因子在这一过程中所扮演的角色。在这篇综述中,我们主要讨论了 SAE 的突触可塑性,主要目的是说明 SAE 对炎症因子的影响以及炎症因子如何影响突触可塑性。这篇综述可加深我们对认知功能障碍内在机制的理解,并为确定治疗 SAE 的适当靶点提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Biological Changes of Synaptic Plasticity in the Pathological Process of Sepsis-associated Encephalopathy.

Sepsis-associated encephalopathy (SAE) is a form of cognitive and psychological impairment resulting from sepsis, which occurs without any central nervous system infection or structural brain injury. Patients may experience long-term cognitive deficits and psychiatric disorders even after discharge. However, the underlying mechanism remains unclear. As cognitive function and mental disease are closely related to synaptic plasticity, it is presumed that alterations in synaptic plasticity play an essential role in the pathological process of SAE. Here, we present a systematic description of the pathogenesis of SAE, which is primarily driven by glial cell activation and subsequent release of inflammatory mediators. Additionally, we elucidate the alterations in synaptic plasticity that occur during SAE and comprehensively discuss the roles played by glial cells and inflammatory factors in this process. In this review, we mainly discuss the synaptic plasticity of SAE, and the main aim is to show the consequences of SAE on inflammatory factors and how they affect synaptic plasticity. This review may enhance our understanding of the mechanism underlying cognitive dysfunction and provide valuable insights into identifying appropriate therapeutic targets for SAE.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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