神经精神药理学:通过 Arc/Arg3.1 调节塑造神经可塑性。

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Francesca Mottarlini, Lucia Caffino, Fabio Fumagalli, Francesca Calabrese, Paola Brivio
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引用次数: 0

摘要

活动调节细胞骨架相关蛋白(又名活动调节基因 Arg3.1)属于效应基因家族的即时早期基因。该家族编码的效应蛋白直接影响细胞的平衡和功能。Arc/Arg3.1定位于树突过程,允许蛋白质按需局部合成,被认为是活动依赖性突触变化的可靠指标。还有证据表明,Arc/Arg3.1 在记忆过程中起着关键作用。Arc/Arg3.1对神经元活动变化的高度敏感性、它的特异性定位以及它对长期突触可塑性的参与,确实使这个效应基因成为精神药物作用的潜在关键靶点。在这篇综述中,我们将重点讨论抗精神病药、抗抑郁药和精神兴奋剂,它们属于滥用药物,但也可用作治疗中枢神经系统特定疾病(如注意力缺陷多动症)的药物。研究表明,具有不同作用机制的精神药物会趋同于 Arc/Arg3.1,从而提供了一种方法,使 Arc/Arg3.1 的突触调节可能有助于它们的治疗活动。我们还讨论了对不同神经精神疾病的潜在转化意义,认识到这些疾病的治疗确实很复杂,涉及到同时调节几种功能紊乱的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NeuropsychopharmARCology: Shaping Neuroplasticity through Arc/Arg3.1 Modulation

Activity-regulated cytoskeletal associated protein (aka activity-regulated gene Arg3.1) belongs to the effector gene family of the immediate early genes. This family encodes effector proteins, which act directly on cellular homeostasis and function. Arc/Arg3.1 is localized at dendritic processes, allowing the protein local synthesis on demand, and it is considered a reliable index of activitydependent synaptic changes. Evidence also exists showing the critical role of Arc/Arg3.1 in memory processes. The high sensitivity to changes in neuronal activity, its specific localization as well as its involvement in long-term synaptic plasticity indeed make this effector gene a potential, critical target of the action of psychotropic drugs. In this review, we focus on antipsychotic and antidepressant drugs as well as on psychostimulants, which belong to the category of drugs of abuse but can also be used as drugs for specific disorders of the central nervous system (i.e., Attention Deficit Hyperactivity Disorder). It is demonstrated that psychotropic drugs with different mechanisms of action converge on Arc/Arg3.1, providing a means whereby Arc/Arg3.1 synaptic modulation may contribute to their therapeutic activity. The potential translational implications for different neuropsychiatric conditions are also discussed, recognizing that the treatment of these disorders is indeed complex and involves the simultaneous regulation of several dysfunctional mechanisms.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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