胰岛素球中的 99mTc-PYP 摄取。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI:10.1097/RLU.0000000000005507

Koji Takahashi, Daisuke Sasaki, Nobuhisa Yamamura, Katsuji Inoue, Takafumi Okura

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引用次数: 0

摘要

摘要：长期皮下注射胰岛素会导致胰岛素注射部位发生组织病理变化，如胰岛素淀粉样变性，从而导致血糖控制不良。胰岛素淀粉样变性通常会形成一个被称为 "胰岛素球 "的结节。胰岛素球尚未在 99mTc-PYP 闪烁扫描中发现。在此，我们描述了一例 74 岁男性胰岛素依赖型糖尿病患者因新发心房颤动导致射血分数保留型心力衰竭的病例。用于心脏淀粉样变性筛查的 99mTc-PYP 闪烁扫描显示心肌中没有示踪剂摄取，但 CT 和 MRI 扫描怀疑的胰岛素球中有摄取。

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99m Tc-PYP Uptake in an Insulin Ball.

Abstract: Long-term subcutaneous insulin injection causes histopathological changes, such as insulin amyloidosis resulting in poor glycemic control, at the insulin injection site. Insulin amyloidosis often leads to the formation of a nodule called the "insulin ball." An insulin ball has not yet been documented on 99m Tc-PYP scintigraphy. Hereby, we describe the case of a 74-year-old man with insulin-requiring diabetes who developed heart failure with preserved ejection fraction due to new-onset atrial fibrillation. 99m Tc-PYP scintigraphy for cardiac amyloidosis screening showed no tracer uptake in the myocardium but did show uptake in the insulin ball suspected by CT and MRI scans.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.