用异维甲酸治疗急性早幼粒细胞白血病患者：病例报告。

IF 0.7 Q4 ONCOLOGY

Case Reports in Oncology Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI:10.1159/000541328

Ilja Goldin, Michael Medinger, Jakob Passweg, Delia Halbeisen

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引用次数: 0

摘要

简介：全反式维甲酸（ATRA）联合三氧化二砷（ATO）是治疗中低风险急性早幼粒细胞白血病（APL）的标准疗法。异维A酸是一种用于治疗寻常痤疮的药物，其化学结构和作用与ATRA相似，单例研究报告显示，异维A酸对APL可能有效：在本病例中，一名新确诊的 APL 患者由于处方错误，使用异维A酸/ATO 代替 ATRA/ATO 治疗了近 4 周，最终与 ATRA/ATO 治疗一样达到了稳定的完全缓解：结论：用异维A酸代替ATRA治疗APL可能有效。

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A Patient with Acute Promyelocytic Leukemia Treated with Isotretinoin: A Case Report.

Introduction: All-trans retinoic acid (ATRA) in combination with arsenic trioxide (ATO) is standard therapy for low-to-intermediate risk acute promyelocytic leukemia (APL). Isotretinoin, an agent used for acne vulgaris, is similar in its chemical structure and effects to ATRA, and single-case studies report a probable effectiveness in APL.

Case presentation: In this case, a patient with newly diagnosed APL was treated with isotretinoin/ATO instead of ATRA/ATO for nearly 4 weeks due to a prescription error and anyway reached a stable complete remission as if treated with ATRA/ATO.

Conclusion: Treatment of APL with isotretinoin instead of ATRA could possibly be effective.

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