英国生物库中的饮食变化与结直肠癌风险。

IF 3.7 3区 医学 Q2 ONCOLOGY
Tung Hoang, Sooyoung Cho, Aesun Shin
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引用次数: 0

摘要

背景:将饮食行为转变为更健康的习惯可能会降低结直肠癌(CRC)风险。本研究旨在调查饮食变化与 CRC 风险之间的关系:根据有关红肉、加工肉类、水果和蔬菜以及饮酒的饮食建议,我们将英国生物库中的 50,640 名参与者分为膳食习惯不良组和膳食习惯良好组。饮食习惯的变化被定义为稳定的不良、从不良到良好、从良好到不良以及从稳定到良好。结果显示,女性更有可能遵循饮食习惯:结果:女性比男性更有可能遵循饮食建议。在最近一次随访的中位数为 3.3 年后,8328 名参与者(16.4%)的饮食习惯有所改善,5808 名参与者(11.5%)的饮食习惯有所恶化。与稳定摄入水果和蔬菜的男性相比 结论:我们的研究结果支持了增加水果和蔬菜摄入量的证据:我们的研究结果支持增加水果和蔬菜摄入量可作为降低男性 CRC 风险的有益策略的证据:英国生物库的参与者在随访期间明显改变了对饮食建议的遵守情况。增加水果和蔬菜的摄入量与男性患 CRC 的风险成反比。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diet changes and colorectal cancer risk in the UK Biobank.

Background: Modifying dietary behaviors into healthier habits may attenuate the risk of colorectal cancer (CRC) risk. This study aimed to investigate the association between dietary changes and the risk of CRC.

Methods: Following dietary recommendations for red and processed meat, fruit and vegetables, and alcohol consumption, we classified 50,640 participants into poor and good adherence groups in the UK Biobank. Changes in dietary habits were defined as stable poor, poor to good, good to poor, and stable to good adherence. A Cox proportional hazard model was used to examine the association between dietary changes and CRC risk.

Results: Women were more likely to follow dietary recommendations than men. After a median of 3.3 years from the latest follow-up, 8,328 (16.4%) participants followed an improved dietary habit and 5,808 (11.5%) participants had a worsened diet. Compared to men who stably consumed fruit and vegetables <5 servings/day, those who increased their consumption to ≥5 servings/day were related to CRC risk reduction (hazard ratio: 0.24, [0.09-0.63]). However, the beneficial associations of increased fruit and vegetable consumption were not statistically significant in women (hazard ratio: 0.41, [0.11-1.56]).

Conclusions: Our findings support the evidence that increasing fruit and vegetable intake could serve as a beneficial strategy to mitigate CRC risk in men.

Impact: Participants from the UK Biobank significantly changes their adherence to dietary recommendations during the follow-up. Increasing fruit and vegetable consumption was inversely associated with CRC risk among men.

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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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