Anna Maurizio, Giorgia Dotto, Antonia Fasoli, Francesco Gaio, Sara Petratti, Alice Pertile, Cinzia Tessarin, Erica Marchiori, Debora Dellamaria, Jaroslav Vadlejch, Rudi Cassini
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The study aimed to assess anthelmintic effectiveness using genus-specific faecal egg count reduction tests (FECRT), to detect differences in treatment response among nematode genera involved in the infection.</p><p><strong>Results: </strong>Twelve farms (6 sheep and 6 goat farms) were included based on clinical suspicion of AR. Treatments were carried out with either benzimidazoles (BZ) or macrocyclic lactones (ML) Treatment was effective in 3/6 goat trials, with reduced effectiveness to BZ in two farms and to ML the last one. In sheep farms (6/6), effectiveness was consistently and more severely insufficient. Ineffectiveness was particularly high towards Haemonchus contortus, while Oesophagostomum/Chabertia maintained susceptibility in nearly all trials. 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引用次数: 0
摘要
背景:抗驱虫药(AR)是放牧畜牧业面临的全球性威胁。在意大利,与其他欧洲国家相比,抗蠕虫药的效力仍然很高,但该国许多地区尚未进行调查。特伦蒂诺大区和威尼托大区的当地兽医报告说,他们的一些农场怀疑抗蠕虫药物无效,这促使他们对意大利北部的绵羊和山羊农场进行了一项关于 AR 的研究。该研究旨在使用特定种属的粪便虫卵计数减少试验(FECRT)评估抗蠕虫药的效果,以检测感染线虫种属对治疗反应的差异:根据临床怀疑,12 个农场(6 个绵羊农场和 6 个山羊农场)被纳入 AR 项目。其中 3/6 的山羊试验有效,2 个农场的 BZ 治疗效果较差,最后一个农场的 ML 治疗效果较差。在绵羊养殖场(6/6)中,疗效一直不足,而且更为严重。对口蹄疫的无效率特别高,而几乎在所有试验中,食道口蹄疫/斜纹口蹄疫都保持着易感性。三代线虫/天牛的效果居中:这项研究揭示了 BZ 和 ML 在意大利东北部小型反刍动物养殖场的疗效减弱,该地区以前缺乏这方面的数据,只有南蒂罗尔的山羊除外。线虫属间治疗反应的差异支持了对 AR 的怀疑,而对高致病性口蹄疫线虫治疗无效的普遍性则进一步引起了人们的关注。这一发现突出表明,迫切需要在该地区进行全面的抗线虫监测,并改进管理方法,以防止抗药性的进一步发展,保护牲畜健康。
Treatment ineffectiveness towards Haemonchus contortus is highly prevalent in sheep and goat farms of North-Eastern Italy.
Background: Anthelmintic resistance (AR) is a global threat to grazing livestock farming. In Italy, anthelmintic efficacy remains high compared to other European countries, but many parts of the country haven't been investigated yet. Local veterinary practitioners from Trentino and Veneto regions reported suspected inefficacy towards anthelmintic drugs in some of their farms, prompting a study on AR in sheep and goat farms of northern Italy. The study aimed to assess anthelmintic effectiveness using genus-specific faecal egg count reduction tests (FECRT), to detect differences in treatment response among nematode genera involved in the infection.
Results: Twelve farms (6 sheep and 6 goat farms) were included based on clinical suspicion of AR. Treatments were carried out with either benzimidazoles (BZ) or macrocyclic lactones (ML) Treatment was effective in 3/6 goat trials, with reduced effectiveness to BZ in two farms and to ML the last one. In sheep farms (6/6), effectiveness was consistently and more severely insufficient. Ineffectiveness was particularly high towards Haemonchus contortus, while Oesophagostomum/Chabertia maintained susceptibility in nearly all trials. Trichostrongylus/Teladorsagia exhibited intermediate results.
Conclusions: This study reveals diminished efficacy of both BZ and ML in small ruminant farms in north-eastern Italy, an area previously lacking data on the topic, except for goats in South Tyrol. Variability in treatment responses among nematode genera support suspicions of AR, and further concerns are raised by the prevalence of treatment ineffectiveness against the highly pathogenic Haemonchus contortus. This finding underscores the urgent need for comprehensive AR monitoring in the area and improved management practices to prevent further resistance development and protect livestock health.
期刊介绍:
BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.