Isabel Di Rosa, Mina Halimitabrizi, Rebecca Salowe, Patrick Augello, Di Zhu, Yineng Chen, Prithvi Sankar, Victoria Addis, Gui-Shuang Ying, Joan O'Brien
{"title":"低体重指数使非洲血统的人患原发性开角型青光眼的风险更高。","authors":"Isabel Di Rosa, Mina Halimitabrizi, Rebecca Salowe, Patrick Augello, Di Zhu, Yineng Chen, Prithvi Sankar, Victoria Addis, Gui-Shuang Ying, Joan O'Brien","doi":"10.1016/j.ajo.2024.10.023","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Investigate the relationship between body mass index (BMI) and primary open-angle glaucoma (POAG) in an African ancestry cohort from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study.</p><p><strong>Design: </strong>Retrospective, cross-sectional \"case-control\" comparison study.</p><p><strong>Methods: </strong>A total of 6,634 POAAGG study subjects were eligible: 2,977 cases and 3,657 controls. Ocular and demographic data were collected from on-site exams, standardized interviews, and electronic medical records. BMI was calculated: weight(kg)/height(m)<sup>2</sup>, and categorized as low (<18.5), moderate (18.5-24.9), high (25.0-29.9), or very high (≥30). Structural and functional POAG progression were assessed by annual rate of change in retinal nerve fiber layer thickness and visual field mean deviation, respectively, using a linear mixed-effects model. Regression analyses evaluated associations of BMI with POAG status, phenotype, and progression.</p><p><strong>Results: </strong>Lower BMI was associated with increased POAG risk (aOR[95% confidence interval], 1.02 [1.007,1.023] per kg/m<sup>2</sup> decrease in BMI, p = .0003). In cases, low BMI was associated with larger cup-to-disc ratio (p = .007) and worse visual acuity (p = .04). Fast functional POAG progressors had a significantly lower mean BMI than slow progressors (25.7 vs. 30.0 kg/m<sup>2</sup>, p = .04).</p><p><strong>Conclusions: </strong>In this African ancestry cohort, low BMI was associated with increased POAG risk. POAG cases with low BMI were more likely to have larger cup-to-disc ratios, worse visual acuity, and faster functional progression, indicating more severe glaucoma.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":"119-126"},"PeriodicalIF":4.1000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Low Body Mass Index Poses Greater Risk of Primary Open-Angle Glaucoma in African Ancestry Individuals.\",\"authors\":\"Isabel Di Rosa, Mina Halimitabrizi, Rebecca Salowe, Patrick Augello, Di Zhu, Yineng Chen, Prithvi Sankar, Victoria Addis, Gui-Shuang Ying, Joan O'Brien\",\"doi\":\"10.1016/j.ajo.2024.10.023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Investigate the relationship between body mass index (BMI) and primary open-angle glaucoma (POAG) in an African ancestry cohort from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study.</p><p><strong>Design: </strong>Retrospective, cross-sectional \\\"case-control\\\" comparison study.</p><p><strong>Methods: </strong>A total of 6,634 POAAGG study subjects were eligible: 2,977 cases and 3,657 controls. Ocular and demographic data were collected from on-site exams, standardized interviews, and electronic medical records. BMI was calculated: weight(kg)/height(m)<sup>2</sup>, and categorized as low (<18.5), moderate (18.5-24.9), high (25.0-29.9), or very high (≥30). Structural and functional POAG progression were assessed by annual rate of change in retinal nerve fiber layer thickness and visual field mean deviation, respectively, using a linear mixed-effects model. Regression analyses evaluated associations of BMI with POAG status, phenotype, and progression.</p><p><strong>Results: </strong>Lower BMI was associated with increased POAG risk (aOR[95% confidence interval], 1.02 [1.007,1.023] per kg/m<sup>2</sup> decrease in BMI, p = .0003). In cases, low BMI was associated with larger cup-to-disc ratio (p = .007) and worse visual acuity (p = .04). Fast functional POAG progressors had a significantly lower mean BMI than slow progressors (25.7 vs. 30.0 kg/m<sup>2</sup>, p = .04).</p><p><strong>Conclusions: </strong>In this African ancestry cohort, low BMI was associated with increased POAG risk. POAG cases with low BMI were more likely to have larger cup-to-disc ratios, worse visual acuity, and faster functional progression, indicating more severe glaucoma.</p>\",\"PeriodicalId\":7568,\"journal\":{\"name\":\"American Journal of Ophthalmology\",\"volume\":\" \",\"pages\":\"119-126\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ajo.2024.10.023\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajo.2024.10.023","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Low Body Mass Index Poses Greater Risk of Primary Open-Angle Glaucoma in African Ancestry Individuals.
Purpose: Investigate the relationship between body mass index (BMI) and primary open-angle glaucoma (POAG) in an African ancestry cohort from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study.
Methods: A total of 6,634 POAAGG study subjects were eligible: 2,977 cases and 3,657 controls. Ocular and demographic data were collected from on-site exams, standardized interviews, and electronic medical records. BMI was calculated: weight(kg)/height(m)2, and categorized as low (<18.5), moderate (18.5-24.9), high (25.0-29.9), or very high (≥30). Structural and functional POAG progression were assessed by annual rate of change in retinal nerve fiber layer thickness and visual field mean deviation, respectively, using a linear mixed-effects model. Regression analyses evaluated associations of BMI with POAG status, phenotype, and progression.
Results: Lower BMI was associated with increased POAG risk (aOR[95% confidence interval], 1.02 [1.007,1.023] per kg/m2 decrease in BMI, p = .0003). In cases, low BMI was associated with larger cup-to-disc ratio (p = .007) and worse visual acuity (p = .04). Fast functional POAG progressors had a significantly lower mean BMI than slow progressors (25.7 vs. 30.0 kg/m2, p = .04).
Conclusions: In this African ancestry cohort, low BMI was associated with increased POAG risk. POAG cases with low BMI were more likely to have larger cup-to-disc ratios, worse visual acuity, and faster functional progression, indicating more severe glaucoma.
期刊介绍：
The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect.
The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports.
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