通过逐层自组装,分层构建超疏水性透明涂层,对眼内透镜进行改性,以减少晶状体的闪烁和防粘连。

IF 5.4 2区 医学 Q1 BIOPHYSICS
Sihao Liu, Xia Zhao, Yuemei Han, Quankui Lin
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引用次数: 0

摘要

人工晶体植入手术是治疗白内障最有效的方法。然而,长期植入人工晶体后,进入的液体微囊所形成的晶莹会严重损害术后视觉质量,目前临床上仍缺乏有效的治疗方法。本研究受天然超疏水表面惊人憎水性的启发,采用逐层静电自组装技术结合氟化技术制备了一种具有超疏水透明涂层的功能化人工晶体材料。在 IOL 材料上交替沉积多种阳离子/阴离子聚电解质和不同大小的二氧化硅纳米颗粒后,对构建的具有特殊表面粗糙度的多层薄膜进一步氟化,以降低表面能。这种多层涂层不仅具有优异的超疏水性和透明度,还能有效消除人工晶体在体外加速条件下形成的闪烁现象。此外,用水滴、细胞和细菌进行的体外实验表明,这种涂层改性材料具有优异的抗粘附性能。体外和体内的生物相容性评估表明,经超疏水和透明涂层修饰的材料具有很好的生物相容性。因此,这种具有优异的超疏水和透明特性的多层涂层可以为人工晶体材料的防闪烁和防粘连提供一种可行的方法。具有特定功能的表面涂层制造工艺的进步将提高改性人工晶体的实际应用和临床成功率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hierarchy-constructed superhydrophobic and transparent coating modified intraocular lens by layer-by-layer self-assembly for glistening reduction and antiadhesion.

Intraocular lens (IOL) implantation surgery is the most effective treatment for cataract. However, glistening formed by the incoming liquid microvacuoles can significantly damage postoperative visual quality after prolonged implantation, for which there is still lack of effective clinical treatment. In this study, inspired by the amazing water-repellency of natural superhydrophobic surface, a functionalized IOL material modified with the superhydrophobic and transparent coating was prepared using layer-by-layer electrostatic self-assembly technique combined with fluorination. After the alternate deposition of multiple cationic/anionic polyelectrolytes and silica nanoparticles of varying sizes on IOL materials, the constructed multilayered films with special surface roughness were further fluorinated to reduce surface energy. In addition to its excellent superhydrophobicity and transparency, this multilayered coating could efficiently eliminate the glistening formation of IOL under accelerated condition in vitro. Furthermore, the in vitro experiments with water droplets, cells, and bacteria suggested the superior antiadhesion property of such coating modified materials. The biocompatibility evaluation, both in vitro and in vivo, demonstrated the great biocompatibility of the materials modified with superhydrophobic and transparent coating. Therefore, this multilayered coating with excellent superhydrophobic and transparent characteristics can provide an available approach aiming at anti-glistening and antiadhesion of IOL materials. Advances in the fabrication process of surface coating with specific functions will enhance the practical application and clinical success of modified IOLs.

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来源期刊
Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces 生物-材料科学:生物材料
CiteScore
11.10
自引率
3.40%
发文量
730
审稿时长
42 days
期刊介绍: Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
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