甲醇溶液中的可卡因和吗啡如何在莱顿弗罗斯特现象辅助热脱附的最后时刻脱附？

IF 1.8 3区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Rapid Communications in Mass Spectrometry Pub Date : 2024-10-30 DOI:10.1002/rcm.9933

Kenzo Hiraoka, Stephanie Rankin-Turner, Dilshadbek T. Usmanov, Sherzod M. Akhmedov, Satoshi Ninomiya

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引用次数: 0

摘要

理由：本研究的目的是调查低挥发性分析物在莱顿弗罗斯特现象辅助热脱附（LPTD）中的脱附情况：方法：采用加热的金属表面（240°C），用粒度从 #5000（约 3 μm）到 #100（约 200 μm）的磨料抛光，对甲醇中 0.03 ppm 可卡因或吗啡的 5 μL 溶液（样品重量：0.12 ng）进行莱顿弗罗斯特现象辅助热脱附研究：只有在甲醇溶剂完全蒸发后才能检测到分析物信号，形成的分析物残留物悬浮在加热器表面。结论：由于被分析物残留物不会从加热器表面脱落，因此不会产生强烈的离子信号：由于溶剂蒸发后分析物残留物并不与加热表面接触，而是悬浮在热基底上，因此分析物的热分解在很大程度上被抑制了。这是 LPTD 用于低挥发性和热敏性化合物痕量分析的一大优点。

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How do cocaine and morphine in methanol solution desorb at the last moment of Leidenfrost phenomenon-assisted thermal desorption?

Rationale

The objective of the present study is to investigate desorption of low-volatility analytes in Leidenfrost phenomenon-assisted thermal desorption (LPTD).

Methods

LPTD was investigated for 5 μL solutions of 0.03 ppm cocaine or morphine in methanol (sample weight: 0.12 ng) by using heated metal surfaces (240°C) polished by abrasives with grit numbers from #5000 (~3 μm) to #100 (~200 μm).

Results

The analyte signals were detected only after the complete evaporation of methanol solvent and the formed analyte residues levitated on the heater surface. The strongest ion signals were obtained with grit number #100.

Conclusions

Because the analyte residue does not come into contact with the heated surface but levitates on the hot substrate after the evaporation of the solvent, thermal decomposition of the analyte is largely suppressed. This is a great merit of LPTD for trace analysis of low-volatility and thermally labile compounds.

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来源期刊

Rapid Communications in Mass Spectrometry 化学-分析化学

CiteScore

4.10

自引率

5.00%

发文量

219

审稿时长

2.6 months

期刊介绍： Rapid Communications in Mass Spectrometry is a journal whose aim is the rapid publication of original research results and ideas on all aspects of the science of gas-phase ions; it covers all the associated scientific disciplines. There is no formal limit on paper length ("rapid" is not synonymous with "brief"), but papers should be of a length that is commensurate with the importance and complexity of the results being reported. Contributions may be theoretical or practical in nature; they may deal with methods, techniques and applications, or with the interpretation of results; they may cover any area in science that depends directly on measurements made upon gaseous ions or that is associated with such measurements.