通过 X-H 插入/环化级联构建基于重氮的杂环系统

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2024-10-30 DOI:10.1002/ejoc.202400909

Ksenia Malkova, Dmitry Dar'in

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引用次数: 0

摘要

本概念概述了 X-H 插入/环化级联（X=对位原子），这是由重氮化合物和 X-H 拴式前体组装 N、O、S-杂环的一个重要策略。在重点研究通过多个键的加成反应实现环化的同时，我们还强调了迈克尔型和科尼亚烯反应、醛醇缩合和曼尼希反应等普遍的关环模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Diazo-Based Construction of Heterocyclic Systems Via a X−H Insertion/Cyclization Cascade

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Diazo-Based Construction of Heterocyclic Systems Via a X−H Insertion/Cyclization Cascade

This Concept outlines an X−H insertion/cyclization cascade (X=heteroatom), a prominent strategy for the assembly of N,O,S-heterocycles from diazo compounds and X−H-tethered precursors. While focusing on the cyclization via an addition to multiple bonds, we have highlighted Michael-type and Conia-ene reactions, aldol condensation, and Mannich reaction as prevalent ring-closing modes.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.