通过单细胞和空间图谱绘制转移性乳腺癌复杂性图谱

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2024-10-30 DOI:10.1038/s41591-024-03308-9

引用次数: 0

摘要

单细胞和空间表达谱分析技术在确定转移性微环境的复杂性方面大有可为，但不同的方法有不同的表现形式。我们使用多达 6 种不同的方法对 67 例转移性乳腺癌活检样本进行了剖析，提供了系统性的比较，并揭示了不同临床病理特征下乳腺癌生物学的空间方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mapping metastatic breast cancer complexity through single-cell and spatial profiling

查看原文本刊更多论文

Mapping metastatic breast cancer complexity through single-cell and spatial profiling

Techniques for single-cell and spatial expression profiling hold great promise for defining the complexity of metastatic microenvironments, but different methods give different representations. We profile 67 biopsies of metastatic breast cancer using up to 6 different methods, provide a systematic comparison and reveal spatial aspects of breast cancer biology across diverse clinicopathological features.

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

期刊介绍： Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.