利用电刺激装置使人类 iPSC 衍生的心脏微纤维成熟（Adv. Healthcare Mater. 27/2024）

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2024-10-28 DOI:10.1002/adhm.202470167

Akari Masuda, Yuta Kurashina, Hidenori Tani, Yusuke Soma, Jumpei Muramatsu, Shun Itai, Shugo Tohyama, Hiroaki Onoe

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引用次数: 0

摘要

体外心脏组织提出了一种用于成熟 hiPSC 衍生的微纤维状心脏组织（心脏微纤维：CMFs）的电刺激系统。在不同频率的电刺激下，CMF通过其肌节长度、电生理特征和基因表达来评估其成熟水平。该模型将有助于不明原因心脏病的病理研究和药物测试。更多详情请见 Shugo Tohyama、Hiroaki Onoe 及合作者撰写的文章 2303477。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Maturation of Human iPSC-Derived Cardiac Microfiber with Electrical Stimulation Device (Adv. Healthcare Mater. 27/2024)

查看原文本刊更多论文

Maturation of Human iPSC-Derived Cardiac Microfiber with Electrical Stimulation Device (Adv. Healthcare Mater. 27/2024)

In Vitro Cardiac Tissue

An electrical stimulation system for maturing hiPSC-derived microfiber-shaped cardiac tissue (cardiac microfibers: CMFs) is proposed. CMFs under electrical stimulation with different frequencies are examined to evaluate the maturation levels by their sarcomere lengths, electrophysiological characteristics, and gene expression. This model will contribute to the pathological research of unexplained cardiac diseases and pharmacologic testing. More details can be found in article 2303477 by Shugo Tohyama, Hiroaki Onoe, and co-workers.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.