封底：基于赖氨酸聚合体的纳米结构抗菌肽用于致龋生物膜微环境激活型龋病治疗

IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-20 DOI:10.1002/agt2.684

Siyuan Li, Feng Wang, Yang Chen, Wanrui Shi, Dashuai Liu, Mingyang Lv, Bin Zhao, Yi Liu, Hao Zhang

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引用次数: 0

摘要

聚合赖氨酸通过破坏细菌膜、干扰新陈代谢和抑制蛋白质合成来模拟抗菌肽（AMPs）。通过 Fe3+ 水解、赖氨酸配位和超小金纳米粒子沉积，FeOOH@Fe-赖氨酸@金显示出类似于 AMP 的抗菌活性和活性氧生成，为龋病生物膜微环境激活型龋病治疗提供了一种有效的方法 (e578)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Back Cover: Lysine aggregates-based nanostructured antimicrobial peptides for cariogenic biofilm microenvironment-activated caries treatment

查看原文本刊更多论文

Back Cover: Lysine aggregates-based nanostructured antimicrobial peptides for cariogenic biofilm microenvironment-activated caries treatment

Aggregated lysine mimics antimicrobial peptides (AMPs) by disrupting bacterial membranes, interfering with metabolism, and inhibiting protein synthesis. With Fe³⁺ hydrolysis, lysine coordination, and ultrasmall Au nanoparticle deposition, FeOOH@Fe-Lysine@Au shows AMP-like antibacterial activity and reactive oxygen species generation, providing an effective approach for cariogenic biofilm microenvironment-activated caries treatment (e578).

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来源期刊

Aggregate (Hoboken, N.J.)

CiteScore

17.40

自引率

0.00%

发文量

审稿时长

7 weeks