作为潜在抗菌剂的新型螺色酮/异噁唑/异噁唑啉衍生物的合成

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2024-10-29 DOI:10.1134/S107036322409024X

M. Raju, Y. Hemasri, Y. Jayaprakash Rao

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引用次数: 0

摘要

在温和的反应条件下，在环保氧化剂（次氯酸钠）存在下，通过相应的螺色酮炔/烯与腈氧化物的 1,3-二极环加成，合成了一系列新型螺色酮和异噁唑/异噁唑啉杂化衍生物。所有新化合物都通过 1H、13C NMR 和 HRMS 技术进行了结构表征。对所有合成化合物的抗菌和抗真菌活性进行了评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of New Class of Spirochromanone/Isoxazole/Isoxazoline Derivatives as Potential Antimicrobial Agents

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Synthesis of New Class of Spirochromanone/Isoxazole/Isoxazoline Derivatives as Potential Antimicrobial Agents

A series of novel hybrid derivatives of spirochromanone and isoxazole/isoxazoline was synthesized by 1,3-dipolar cycloaddition of the corresponding spirochromanone alkyne/alkene with nitrile oxides, in situ generated from substituted oximes in the presence of eco-friendly oxidant (sodium hypochlorite) under mild reaction conditions. All new compounds were structurally characterized by ¹H, ¹³C NMR and HRMS techniques. All synthesized compounds were evaluated for their antimicrobial and antifungal activities.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.