非洲之角孕妇甲状腺功能障碍的患病率：系统回顾与元分析

Q3 Medicine

Endocrine and Metabolic Science Pub Date : 2024-09-30 DOI:10.1016/j.endmts.2024.100200

Marye Nigatie , Getinet Kumie , Abdu Jemal , Solomon Gedfie , Woldeteklehaymanot Kassahun , Muluken Gashaw , Agenagnew Ashagre , Tadesse Misganaw , Wagaw Abebe , Ermias Getachew , Selamyhun Tadesse , Zelalem Dejazmach , Sisay Ayana , Yalewayker Gashaw , Zelalem Asmare , Assefa Sisay , Atitegeb Abera , Biruk Beletew Abate , Melese Abate Reta

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引用次数: 0

摘要

背景甲状腺功能障碍是最常见的内分泌疾病之一。妊娠期甲状腺功能紊乱会对母婴造成不良影响。为了确定相关研究，我们在 Scopus、PubMed、Science Direct 数据库、Google Scholar 和文献库登记中进行了全面搜索，搜索时间为 2000 年 1 月 1 日至 2023 年 12 月 31 日。最终选择了 10 篇相关出版物进行荟萃分析。使用 Microsoft Excel 提取相关数据，并使用 STATA 软件 17 版进行分析，采用随机效应模型。进行了敏感性分析以评估每项研究对结果的影响，并利用 Egger 检验来检测发表偏倚。此外，还进行了修剪填充分析，以调整效应估计值的偏差。使用 Cochran's Q 统计量和 I2 统计量评估了各研究之间的异质性。根据研究设计、国家和发表年份进行了分组分析。结果在这项系统回顾和荟萃分析中，2538 名孕妇的甲状腺功能障碍患病率为 12.0 %（95 % CI：8.00 %-17.00 %）。为了解释所观察到的显著异质性，我们采用了随机效应模型。具体而言，孕妇甲减患病率被确定为 10.00 %（95 % CI：4.00-16.00 %），异质性很高（I2 = 94.27 %，p < 0.001）。值得注意的是，所进行的敏感性分析并未显示出对甲状腺功能障碍总患病率的实质性影响。为了评估治疗甲状腺疾病对妊娠结局的影响并为临床决策提供依据，建议在孕期开展具有成本效益的促甲状腺激素筛查。

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Prevalence of thyroid dysfunction among pregnant women in the horn of Africa: A systematic review and Meta-analysis

Background

Thyroid dysfunction ranks among the most prevalent endocrine disorders. This disorder during pregnancy has been linked to adverse effects on both the mother and the baby. However, there is a scarcity of data and inconsistent documentation regarding thyroid issues in pregnant women in low-income nations.

Objective

The aim of this systematic review and meta-analysis was to determine the general prevalence of thyroid disorders in pregnant women.

Methods

To identify relevant studies, a comprehensive search was conducted across Scopus, PubMed, Science Direct databases, and Google Scholar and repository registers from January 1, 2000 to December 31, 2023. Ten pertinent publications were chosen for the final meta-analysis. Relevant data was extracted using Microsoft Excel and analyzed using STATA software version 17, employing a random-effect model. Sensitivity analysis was conducted to evaluate each study's impact on the outcome, and Egger's test was utilized to detect publication bias. A trim-and-fill analysis was executed to adjust for bias in the effect estimate. Heterogeneity across studies was assessed using Cochran's Q statistic and I² statistics. Subgroup analysis was carried by study design, country and publication year.

Results

In this systematic review and meta-analysis, the prevalence of thyroid dysfunction among 2538 pregnant women was 12.0 % (95 % CI: 8.00 %–17.00 %). To account for the significant heterogeneity observed, a random effect model was utilized. Specifically, the prevalence of hypothyroidism in pregnant women was determined to be 10.00 % (95 % CI: 4.00–16.00 %) with a high level of heterogeneity (I² = 94.27 %, p < 0.001). Notably, the sensitivity analysis conducted did not reveal any substantial impact on the overall pooled prevalence of thyroid dysfunction.

Conclusion

The meta-analysis revealed a significantly higher rate of thyroid disorders among pregnant women compared to global estimates. To assess the effects of treating thyroid conditions on pregnancy outcomes and inform clinical decisions, it is recommended to implement cost-effective thyroid-stimulating hormone screening during pregnancy.

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来源期刊

Endocrine and Metabolic Science Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

84 days