新型、低成本、环保型替加环素合成途径

IF 3.2 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2024-10-24 DOI:10.1016/j.jics.2024.101441

Vandanaben Bhupatray Sompura , Rizwan Y. Ghumara , Naresh RanajiKiri , Tarunkumar N. Akhaja , Tushar Ravjibhai Sutariya , Samat Rama Ram , Jignesh Priyakant Raval , Keyur kumar A. Kamani

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引用次数: 0

摘要

替加环素对耐四环素细菌有效，其研发始于其前体--9-氨基米诺环素的合成，米诺环素是通过硝化从盐酸米诺环素中提取的。水作为主要溶剂，确保了加工过程的成本效益。在最后一步，转化为替加环素只需将盐酸叔丁基甘氨酰氯作为反应物。这种方法显示了可持续生产替加环素的巨大潜力，使其更容易大规模用作抗生素。在整个合成过程中，使用了红外光谱、1H NMR、13C NMR 和质谱分析等多种技术来表征不同阶段的每种产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Novel, low-cost, and environmentally friendly pathway for synthesizing tigecycline

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Novel, low-cost, and environmentally friendly pathway for synthesizing tigecycline

The development of tigecycline, effective against tetracycline-resistant bacteria, began with the synthesis of its precursor, 9-amino minocycline, derived from minocycline hydrochloride through nitration. Water served as the primary solvent, ensuring cost-effective processing. In the final step, conversion to tigecycline required only tert-butylglycinoyl chloride hydrochloride as a reactant. This method shows great potential for the sustainable production of tigecycline, making it more accessible for large-scale use as an antibiotic. Throughout the synthesis, various techniques such as IR, ¹H NMR, ¹³C NMR, and mass spectrometry were used to characterize each product at different stages.

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.