苯并咪唑盐对肺癌、肝癌和结肠癌细胞系的细胞毒活性特性

IF 3.2 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2024-10-22 DOI:10.1016/j.jics.2024.101445

Senem Akkoc

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引用次数: 0

摘要

本研究以 N-苯基邻苯二胺为起点，分两步合成了一种已知的苯并咪唑盐。该化合物针对不同的癌细胞株（A549-肺癌、HepG2-肝癌、DLD-1-结肠癌）进行了 72 小时的体外测试，并将其活性与广泛使用的化疗药物顺铂进行了比较。通过使用 MTT 法检测该化合物的细胞毒性作用 IC50 值，评估了化合物 4 作为潜在抗癌剂对不同癌症类型的作用。结果发现，化合物 4 在不同的细胞类型中表现出不同的活性，尤其是在 72 小时的培养时间内对肺癌细胞株具有较高的细胞毒性作用（IC50：15.68 μM）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cytotoxic activity properties of a benzimidazolium salt against lung, liver, and colon cancer cell lines

查看原文本刊更多论文

Cytotoxic activity properties of a benzimidazolium salt against lung, liver, and colon cancer cell lines

In this study, a known benzimidazolium salt was synthesized in two steps starting from N-phenyl-o-phenylenediamine. This compound was tested in vitro for 72 h against different cancer cell lines (A549 - lung cancer, HepG2 - liver cancer, DLD-1 - colon cancer) and to compare the activity of this compound with cisplatin, a widely used chemotherapeutic agent. The evaluation of compound 4 as a potential anticancer agent against different cancer types was achieved by examining the cytotoxic effects of this compound through IC50 values using the MTT method. It was found that compound 4 showed different activity depending on the cell type and had a high cytotoxic effect (IC₅₀: 15.68 μM), especially against lung cancer cell line for 72 h incubation time.

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.