肠簇细胞可作为抗损伤干细胞

IF 5.7 1区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Chemical Theory and Computation Pub Date : 2024-10-29 DOI:10.1038/s41575-024-01016-w

Caroline Barranco

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引用次数: 0

摘要

黄等人（Huang et al）在《自然》（Nature）杂志上报告说，人类丛细胞的子集终生保持增殖能力，可作为损伤诱导的再生干细胞池。研究人员从单个成熟增殖的人类丛细胞中生成了包含所有人类肠道细胞类型的器官组织。与含有簇状细胞的有机体不同，缺乏簇状细胞的有机体在辐照后不会再生。虽然含有富亮氨酸重复的G蛋白偶联受体5（LGR5）的细胞是最常见的肠干细胞类型，但它们对损伤高度敏感。因此，在失去LGR5+细胞后，丛细胞可提供后备干细胞池。

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Intestinal tuft cells can act as injury-resistant stem cells

Subsets of human tuft cells retain their proliferative capacity throughout life and can act as a damage-induced pool of regenerative stem cells, report Huang et al. in Nature.

Organoids containing all human intestinal cell types were generated by the researchers from a single mature proliferating human tuft cell. Organoids engineered to lack tuft cells did not regenerate after irradiation, unlike those containing tuft cells. Although cells bearing leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) are the most common intestinal stem cell type, they are highly sensitive to injury. Therefore, tuft cells could provide a reserve stem cell pool after loss of LGR5⁺ cells.

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来源期刊

Journal of Chemical Theory and Computation 化学-物理：原子、分子和化学物理

CiteScore

9.90

自引率

16.40%

发文量

568

审稿时长

1 months

期刊介绍： The Journal of Chemical Theory and Computation invites new and original contributions with the understanding that, if accepted, they will not be published elsewhere. Papers reporting new theories, methodology, and/or important applications in quantum electronic structure, molecular dynamics, and statistical mechanics are appropriate for submission to this Journal. Specific topics include advances in or applications of ab initio quantum mechanics, density functional theory, design and properties of new materials, surface science, Monte Carlo simulations, solvation models, QM/MM calculations, biomolecular structure prediction, and molecular dynamics in the broadest sense including gas-phase dynamics, ab initio dynamics, biomolecular dynamics, and protein folding. The Journal does not consider papers that are straightforward applications of known methods including DFT and molecular dynamics. The Journal favors submissions that include advances in theory or methodology with applications to compelling problems.