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来自 Rhodococcus 的隐性迭代多酮合成酶形成扩展多烯

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Chemical Communications Pub Date : 2024-11-01 DOI:10.1039/d4cc04963b
Panward Prasongpholchai , Sam Tucker , Charles Burgess , Robert Jenkins , Ina Wilkening , Christophe Corre , Lijiang Song , Manuela Tosin
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引用次数: 0

摘要

许多具有生物活性的天然产物，包括聚酮苷和仲脂肪酸，都是由放线菌中的多功能酶进行生物合成的。我们从海洋微生物 Rhodococcus erythropolis PR4 中发现了一种迭代多酮合成酶（iPKS），并通过在大肠杆菌中重组蛋白表达、定点诱变、体内外酶功能重组以及使用（生物）化学探针确定了其工作原理。事实证明，iPKS 能够生成长达 C22 共轭壬烯的新型线性多烯，这是前所未有的，为从一种不寻常的天然产品来源中获得新型化学和产品奠定了基础。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus†

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Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus†
Many reactive intermediates leading to high value molecules are biosynthesised by multifunctional enzymes in Actinobacteria. Herein we report the workings of a cryptic iterative polyketide synthase (iPKS) from the marine microorganism Rhodococcus erythropolis PR4. The iPKS generates extended polyenes up to C22 nonaenes, preluding novel chemistry and biology.
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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