Nae-Un Kang , Ga Hyun Kim , Hee-Kyeong Kim , Se Hun Kim , Young Yul Kim , Hyun-Ha Park , Young-Sam Cho
{"title":"聚乙二醇二甲基丙烯酸酯(PEGDMA)多功能柱状图案表面用于前成骨细胞的成骨分化以及对大肠杆菌和金黄色葡萄球菌的抗菌作用","authors":"Nae-Un Kang , Ga Hyun Kim , Hee-Kyeong Kim , Se Hun Kim , Young Yul Kim , Hyun-Ha Park , Young-Sam Cho","doi":"10.1016/j.surfin.2024.105221","DOIUrl":null,"url":null,"abstract":"<div><div>Cells are sensitive to the surface topographical environment, which can subsequently induce changes in cell morphology, cytoskeleton, and differentiation. Therefore, the topological environment in bone implant devices is known to influence the cell behavior, adhesion, and differentiation of osteoblasts. Furthermore, bone implant devices with anti-bacterial properties could be necessary to prevent surgical site infections (SSIs). Consequently, there is a demand for research into multi-functional surfaces that can facilitate osteoblast differentiation while also possessing an anti-bacterial effect. In this study, we fabricated and assessed the poly(ethylene glycol) dimethacrylate (PEGDMA) nano/micro pillar-patterned surface to find the optimized dimensional characteristics of the pillar pattern for multi-functional effect. Results observed that the pillar pattern enhanced differentiation to osteoblast on the pillar-patterned surface (D1S0.5) having pillars with 0.5 μm height, 1 μm diameter, and 0.5 μm spacing between pillars and pillar-patterned surface (D1S1) having pillars with 0.5 μm height, 1 μm diameter, and 1 μm spacing between pillars. Subsequently, results of evaluating anti-bacterial effect revealed that the optimized pillar-patterned surface exhibited remarkable antibacterial effect, with the D1S0.5 pillar-patterned surface showing the highest antibacterial effect. Consequently, this study proposed and verified a multi-functional pillar-patterned surface capable of promoting osteoblast differentiation with anti-bacterial effects.</div></div>","PeriodicalId":22081,"journal":{"name":"Surfaces and Interfaces","volume":"55 ","pages":"Article 105221"},"PeriodicalIF":5.7000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Poly(ethylene glycol) dimethacrylate (PEGDMA) multi-functional pillar-patterned surface for osteogenic differentiation of pre-osteoblast and anti-bacterial effects to Escherichia coli and Staphylococcus aureus\",\"authors\":\"Nae-Un Kang , Ga Hyun Kim , Hee-Kyeong Kim , Se Hun Kim , Young Yul Kim , Hyun-Ha Park , Young-Sam Cho\",\"doi\":\"10.1016/j.surfin.2024.105221\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Cells are sensitive to the surface topographical environment, which can subsequently induce changes in cell morphology, cytoskeleton, and differentiation. Therefore, the topological environment in bone implant devices is known to influence the cell behavior, adhesion, and differentiation of osteoblasts. Furthermore, bone implant devices with anti-bacterial properties could be necessary to prevent surgical site infections (SSIs). Consequently, there is a demand for research into multi-functional surfaces that can facilitate osteoblast differentiation while also possessing an anti-bacterial effect. In this study, we fabricated and assessed the poly(ethylene glycol) dimethacrylate (PEGDMA) nano/micro pillar-patterned surface to find the optimized dimensional characteristics of the pillar pattern for multi-functional effect. Results observed that the pillar pattern enhanced differentiation to osteoblast on the pillar-patterned surface (D1S0.5) having pillars with 0.5 μm height, 1 μm diameter, and 0.5 μm spacing between pillars and pillar-patterned surface (D1S1) having pillars with 0.5 μm height, 1 μm diameter, and 1 μm spacing between pillars. Subsequently, results of evaluating anti-bacterial effect revealed that the optimized pillar-patterned surface exhibited remarkable antibacterial effect, with the D1S0.5 pillar-patterned surface showing the highest antibacterial effect. Consequently, this study proposed and verified a multi-functional pillar-patterned surface capable of promoting osteoblast differentiation with anti-bacterial effects.</div></div>\",\"PeriodicalId\":22081,\"journal\":{\"name\":\"Surfaces and Interfaces\",\"volume\":\"55 \",\"pages\":\"Article 105221\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2024-10-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Surfaces and Interfaces\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468023024013774\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surfaces and Interfaces","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468023024013774","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Poly(ethylene glycol) dimethacrylate (PEGDMA) multi-functional pillar-patterned surface for osteogenic differentiation of pre-osteoblast and anti-bacterial effects to Escherichia coli and Staphylococcus aureus
Cells are sensitive to the surface topographical environment, which can subsequently induce changes in cell morphology, cytoskeleton, and differentiation. Therefore, the topological environment in bone implant devices is known to influence the cell behavior, adhesion, and differentiation of osteoblasts. Furthermore, bone implant devices with anti-bacterial properties could be necessary to prevent surgical site infections (SSIs). Consequently, there is a demand for research into multi-functional surfaces that can facilitate osteoblast differentiation while also possessing an anti-bacterial effect. In this study, we fabricated and assessed the poly(ethylene glycol) dimethacrylate (PEGDMA) nano/micro pillar-patterned surface to find the optimized dimensional characteristics of the pillar pattern for multi-functional effect. Results observed that the pillar pattern enhanced differentiation to osteoblast on the pillar-patterned surface (D1S0.5) having pillars with 0.5 μm height, 1 μm diameter, and 0.5 μm spacing between pillars and pillar-patterned surface (D1S1) having pillars with 0.5 μm height, 1 μm diameter, and 1 μm spacing between pillars. Subsequently, results of evaluating anti-bacterial effect revealed that the optimized pillar-patterned surface exhibited remarkable antibacterial effect, with the D1S0.5 pillar-patterned surface showing the highest antibacterial effect. Consequently, this study proposed and verified a multi-functional pillar-patterned surface capable of promoting osteoblast differentiation with anti-bacterial effects.
期刊介绍:
The aim of the journal is to provide a respectful outlet for ''sound science'' papers in all research areas on surfaces and interfaces. We define sound science papers as papers that describe new and well-executed research, but that do not necessarily provide brand new insights or are merely a description of research results.
Surfaces and Interfaces publishes research papers in all fields of surface science which may not always find the right home on first submission to our Elsevier sister journals (Applied Surface, Surface and Coatings Technology, Thin Solid Films)