Tolulope Fashina , Nam V. Nguyen , Ye Huang , Casey Randleman , Caleb D. Hartley , John G. Mattia , Matthew J. Vandy , Lloyd C. Harrison-Williams , Jalikatu Mustapha , Jean-Claude Mwanza , Brent R. Hayek , Ian Crozier , Jessica G. Shantha , Steven Yeh
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Demographic (including age, sex, and the number of days spent in the Ebola treatment unit and examination (such as visual acuity, and ocular complications) data were collected and used for the analysis. Visual acuity was either uncorrected or corrected with spectacles. Descriptive and inferential statistical analyses were performed, and a p-value < 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>A total of 242 eyes (121 patients) were included in this study. The mean age was 31.5 ± 16.1 years, and 70 % were female. Of 242 eyes, 28 (11.5 %) eyes of 15 patients (12.4 %) presented with at least one or more corneal or conjunctival abnormalities. Within eyes that demonstrated CCAs, the findings included dry eye (28.6 % of eyes), band keratopathy (25 % of eyes), and corneal scar (21.4 % of eyes). Corneal edema was found in 14.3 % of eyes, while pterygium and epithelial bullae were each found in 7.1 % of affected eyes. Patients without CCAs had better visual acuity compared to patients with CCAs although the difference was not statistically significant (0.82 ± 1.17 vs 1.01 ± 1.29, p = 0.4). A subset of patients with CCAs also reported ocular symptoms including eye pain, light sensitivity, excessive tearing, and blurry vision.</div></div><div><h3>Conclusion</h3><div>In this post hoc analysis, we observed CCAs in 12 % of EVD survivors. These findings highlight the potential for corneal and conjunctival sequelae during EVD survivorship and the need for ongoing ophthalmic care for this vulnerable population.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"1 4","pages":"Article 100075"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Corneal and conjunctival abnormalities in a cohort of survivors from the Western African Ebola virus disease outbreak\",\"authors\":\"Tolulope Fashina , Nam V. Nguyen , Ye Huang , Casey Randleman , Caleb D. Hartley , John G. Mattia , Matthew J. Vandy , Lloyd C. Harrison-Williams , Jalikatu Mustapha , Jean-Claude Mwanza , Brent R. Hayek , Ian Crozier , Jessica G. Shantha , Steven Yeh\",\"doi\":\"10.1016/j.ajoint.2024.100075\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>To characterize corneal and conjunctival abnormalities (CCAs) and their impact on visual acuity in a cohort of survivors from the Western African Ebola virus disease (EVD) outbreak.</div></div><div><h3>Design</h3><div>A post hoc analysis of 121 patients, who had previously undergone screening for the Ebola Virus Persistence in Ocular Tissues and Fluids study, was performed.</div></div><div><h3>Methods</h3><div>Patients underwent a comprehensive ophthalmic exam at the Lowell and Ruth Gess Eye Hospital in Freetown, Sierra Leone. Demographic (including age, sex, and the number of days spent in the Ebola treatment unit and examination (such as visual acuity, and ocular complications) data were collected and used for the analysis. Visual acuity was either uncorrected or corrected with spectacles. Descriptive and inferential statistical analyses were performed, and a p-value < 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>A total of 242 eyes (121 patients) were included in this study. The mean age was 31.5 ± 16.1 years, and 70 % were female. Of 242 eyes, 28 (11.5 %) eyes of 15 patients (12.4 %) presented with at least one or more corneal or conjunctival abnormalities. Within eyes that demonstrated CCAs, the findings included dry eye (28.6 % of eyes), band keratopathy (25 % of eyes), and corneal scar (21.4 % of eyes). Corneal edema was found in 14.3 % of eyes, while pterygium and epithelial bullae were each found in 7.1 % of affected eyes. Patients without CCAs had better visual acuity compared to patients with CCAs although the difference was not statistically significant (0.82 ± 1.17 vs 1.01 ± 1.29, p = 0.4). A subset of patients with CCAs also reported ocular symptoms including eye pain, light sensitivity, excessive tearing, and blurry vision.</div></div><div><h3>Conclusion</h3><div>In this post hoc analysis, we observed CCAs in 12 % of EVD survivors. 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引用次数: 0
摘要
目的了解西非埃博拉病毒病（EVD）疫情幸存者中角膜和结膜异常（CCA）的特征及其对视力的影响。方法患者在塞拉利昂弗里敦的洛厄尔和露丝-盖斯眼科医院接受了全面的眼科检查。我们收集了人口统计学数据（包括年龄、性别和在埃博拉治疗病房的天数）和检查数据（如视力和眼部并发症），并将其用于分析。视力为未矫正或戴眼镜矫正的视力。本研究共纳入 242 只眼睛（121 名患者）。平均年龄为 31.5 ± 16.1 岁，70% 为女性。在 242 只眼睛中，有 15 名患者（12.4%）的 28 只眼睛（11.5%）出现至少一种或多种角膜或结膜异常。在出现 CCA 的眼睛中，发现的病症包括干眼症（28.6% 的眼睛）、带状角膜病（25% 的眼睛）和角膜瘢痕（21.4% 的眼睛）。14.3%的患者出现角膜水肿，7.1%的患者出现翼状胬肉和上皮水泡。与患有 CCA 的患者相比，未患 CCA 的患者视力较好，但差异无统计学意义（0.82 ± 1.17 vs 1.01 ± 1.29，P = 0.4）。一部分患有 CCA 的患者还报告了眼部症状，包括眼痛、光敏感、过度流泪和视力模糊。这些发现凸显了在 EVD 存活期间角膜和结膜后遗症的可能性，以及对这一弱势群体进行持续眼科护理的必要性。
Corneal and conjunctival abnormalities in a cohort of survivors from the Western African Ebola virus disease outbreak
Purpose
To characterize corneal and conjunctival abnormalities (CCAs) and their impact on visual acuity in a cohort of survivors from the Western African Ebola virus disease (EVD) outbreak.
Design
A post hoc analysis of 121 patients, who had previously undergone screening for the Ebola Virus Persistence in Ocular Tissues and Fluids study, was performed.
Methods
Patients underwent a comprehensive ophthalmic exam at the Lowell and Ruth Gess Eye Hospital in Freetown, Sierra Leone. Demographic (including age, sex, and the number of days spent in the Ebola treatment unit and examination (such as visual acuity, and ocular complications) data were collected and used for the analysis. Visual acuity was either uncorrected or corrected with spectacles. Descriptive and inferential statistical analyses were performed, and a p-value < 0.05 was considered statistically significant.
Results
A total of 242 eyes (121 patients) were included in this study. The mean age was 31.5 ± 16.1 years, and 70 % were female. Of 242 eyes, 28 (11.5 %) eyes of 15 patients (12.4 %) presented with at least one or more corneal or conjunctival abnormalities. Within eyes that demonstrated CCAs, the findings included dry eye (28.6 % of eyes), band keratopathy (25 % of eyes), and corneal scar (21.4 % of eyes). Corneal edema was found in 14.3 % of eyes, while pterygium and epithelial bullae were each found in 7.1 % of affected eyes. Patients without CCAs had better visual acuity compared to patients with CCAs although the difference was not statistically significant (0.82 ± 1.17 vs 1.01 ± 1.29, p = 0.4). A subset of patients with CCAs also reported ocular symptoms including eye pain, light sensitivity, excessive tearing, and blurry vision.
Conclusion
In this post hoc analysis, we observed CCAs in 12 % of EVD survivors. These findings highlight the potential for corneal and conjunctival sequelae during EVD survivorship and the need for ongoing ophthalmic care for this vulnerable population.
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