荚果科植物的分布、分类、系统发育、植物化学、药理学以及为生产荚果毒素而进行的人工栽培

IF 5.6 1区农林科学 Q1 AGRICULTURAL ENGINEERING

Industrial Crops and Products Pub Date : 2024-10-21 DOI:10.1016/j.indcrop.2024.119862

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引用次数: 0

摘要

鬼臼毒素（Podophyllotoxin，PPT）是一种芳基四氢木质素，主要存在于中国鬼臼（Sinopodophyllum hexandrum）和盾叶鬼臼（Podophyllum peltatum）的根茎中。为了拓宽鬼臼科植物的工业用途，我们对其分布、分类、系统发育、植物化学、药理和人工栽培进行了总结。目前，荚蒾科有四个属（即荚蒾属、 Sinopodophyllum 属、Diphylleia 属和 Dysosma 属），13 个种（即、Podophyllum peltatum、S. hexandrum、Diphylleia cymosa、D. sinensis、D. grayi、Dysosma aurantiocaulis、D. delavayi、D. difformis、D. majoensis、D. pleiantha、D. tsayuensis、D. versipellis 和 D. villosa）。根据这 13 个种的形态特征，更新了它们的属键。根据叶绿体基因组构建了系统发生。约有43 种化学成分，包括26 种木酚素、9 种黄酮类化合物和其他 8 种成分。同时，PPT 的含量差异很大，其中 S. hexandrum 的含量最高（约 11%），其次是 D. tsayuensis（约 1.5%）和 D. grayi（约 1.3%）。PPT 及其衍生物主要用于癌症化疗。目前，已按照良好农业规范（GAP）实现了六味地黄丸的大规模仿生野生栽培，并利用遮阳网覆盖建立了七味地黄丸的人工栽培，其他 11 个物种的尝试正在进行中。到目前为止，S. hexandrum 是生产 PPT 的首选品种，而 D. versipellis 将是替代植物材料。此外，寻找可持续的方法来保护荚蒾科植物，如快速繁殖、生态种植和合理采收，也是非常必要和紧迫的。本综述将为合理探索和利用鬼臼科植物生产 PPT 提供有益参考。

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Distribution, taxonomy, phylogeny, phytochemistry, pharmacology, and artificial cultivation of tribe Podophylleae for podophyllotoxin production

Podophyllotoxin (PPT) is an aryltetralin lignan incipiently found in the rhizomes of Sinopodophyllum hexandrum and Podophyllum peltatum. To broaden the industrial use of tribe Podophylleae, the distribution, taxonomy, phylogeny, phytochemistry, pharmacology, and artificial cultivation were summarized. Currently, there are four genera (i.e., Podophyllum, Sinopodophyllum, Diphylleia, and Dysosma) with 13 species (i.e., Podophyllum peltatum, S. hexandrum, Diphylleia cymosa, D. sinensis, D. grayi, Dysosma aurantiocaulis, D. delavayi, D. difformis, D. majoensis, D. pleiantha, D. tsayuensis, D. versipellis, and D. villosa) in the tribe Podophylleae. The key to the genera of the 13 species was renewed based on their morphological characteristics. The phylogeny was constructed according to the chloroplast genomes. There are ca. 43 chemical constituents including: 26 lignans, 9 flavonoids, and other 8 constituents identified from the 12 species (except for the D. villosa). Meanwhile, there is a significant variation in PPT content with a highest level (ca. 11 %) in the S. hexandrum, followed by D. tsayuensis (ca. 1.5 %) and D. grayi (ca. 1.3 %). The PPT and its derivatives are mainly used for chemotherapy agents of cancers. Presently, a large-scale bionic wild cultivation of S. hexandrum has been achieved following good agricultural practices (GAP), and artificial cultivation of D. versipellis has been established using sunshading-net coverage, while the attemptation of other 11 species is on the way. To date, S. hexandrum is the preferred species for the PPT production, and D. versipellis would be the alternative plant materials. Additionally, it is necessary and urgent to find out sustainable approaches to protect the tribe Podophylleae, such as rapid propagation, ecological planting, and rational harvest. This review will provide useful references for the reasonable exploration and utilization of tribe Podophylleae for PPT production.

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来源期刊

Industrial Crops and Products 农林科学-农业工程

CiteScore

9.50

自引率

8.50%

发文量

1518

审稿时长

43 days

期刊介绍： Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.