纳米体--自身免疫性疾病中出现的多功能工具

Q1 Engineering
Ling Wang , Ran Luo , Weilang Zhang , Hanyu Jiang , Yongkang Yu , Wenhu Zhou , Fan Zhang , Jian Ma , Lin Mei
{"title":"纳米体--自身免疫性疾病中出现的多功能工具","authors":"Ling Wang ,&nbsp;Ran Luo ,&nbsp;Weilang Zhang ,&nbsp;Hanyu Jiang ,&nbsp;Yongkang Yu ,&nbsp;Wenhu Zhou ,&nbsp;Fan Zhang ,&nbsp;Jian Ma ,&nbsp;Lin Mei","doi":"10.1016/j.smaim.2024.10.003","DOIUrl":null,"url":null,"abstract":"<div><div>Nanobody (Nb) is derived from the variable domain of heavy-chain antibody (HCAb), naturally displaying notable properties like nano-scale size, exceptional stability, high specificity, low immunogenicity, and cryptic epitope accessibility. These features contribute to its great therapeutic potential as a valuable research tool across diverse diseases, especially autoimmune diseases (AIDs). Caplacizumab (Cablivi®) is the first nanobody drug approved for treating acquired thrombotic thrombocytopenic purpura (aTTP). This review summarizes the biomolecular structure, usage of Nb as a foundation of recombinant constructs, and biochemical properties of nanobodies. As attractive therapeutic candidates, many clinical trials of Nbs have been conducted, elucidating potential therapeutic strategies for AIDs. Therefore, the preclinical development and application of Nbs in AIDs are emphasized throughout this review.</div></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanobody-as versatile tool emerging in autoimmune diseases\",\"authors\":\"Ling Wang ,&nbsp;Ran Luo ,&nbsp;Weilang Zhang ,&nbsp;Hanyu Jiang ,&nbsp;Yongkang Yu ,&nbsp;Wenhu Zhou ,&nbsp;Fan Zhang ,&nbsp;Jian Ma ,&nbsp;Lin Mei\",\"doi\":\"10.1016/j.smaim.2024.10.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Nanobody (Nb) is derived from the variable domain of heavy-chain antibody (HCAb), naturally displaying notable properties like nano-scale size, exceptional stability, high specificity, low immunogenicity, and cryptic epitope accessibility. These features contribute to its great therapeutic potential as a valuable research tool across diverse diseases, especially autoimmune diseases (AIDs). Caplacizumab (Cablivi®) is the first nanobody drug approved for treating acquired thrombotic thrombocytopenic purpura (aTTP). This review summarizes the biomolecular structure, usage of Nb as a foundation of recombinant constructs, and biochemical properties of nanobodies. As attractive therapeutic candidates, many clinical trials of Nbs have been conducted, elucidating potential therapeutic strategies for AIDs. Therefore, the preclinical development and application of Nbs in AIDs are emphasized throughout this review.</div></div>\",\"PeriodicalId\":22019,\"journal\":{\"name\":\"Smart Materials in Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Smart Materials in Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590183424000528\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Smart Materials in Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590183424000528","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 0

摘要

纳米抗体(Nb)源自重链抗体(HCAb)的可变结构域,天然具有纳米级尺寸、超强稳定性、高特异性、低免疫原性和表位隐蔽性等显著特性。这些特性使其具有巨大的治疗潜力,成为各种疾病,尤其是自身免疫性疾病(AIDs)的重要研究工具。卡普拉珠单抗(Cablivi®)是首个获准用于治疗获得性血栓性血小板减少性紫癜(aTTP)的纳米抗体药物。本综述概述了纳米抗体的生物分子结构、作为重组构建物基础的 Nb 的使用以及纳米抗体的生化特性。作为极具吸引力的候选治疗药物,Nbs 已经开展了许多临床试验,阐明了治疗艾滋病的潜在策略。因此,本综述强调了 Nbs 在艾滋病中的临床前开发和应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nanobody-as versatile tool emerging in autoimmune diseases

Nanobody-as versatile tool emerging in autoimmune diseases
Nanobody (Nb) is derived from the variable domain of heavy-chain antibody (HCAb), naturally displaying notable properties like nano-scale size, exceptional stability, high specificity, low immunogenicity, and cryptic epitope accessibility. These features contribute to its great therapeutic potential as a valuable research tool across diverse diseases, especially autoimmune diseases (AIDs). Caplacizumab (Cablivi®) is the first nanobody drug approved for treating acquired thrombotic thrombocytopenic purpura (aTTP). This review summarizes the biomolecular structure, usage of Nb as a foundation of recombinant constructs, and biochemical properties of nanobodies. As attractive therapeutic candidates, many clinical trials of Nbs have been conducted, elucidating potential therapeutic strategies for AIDs. Therefore, the preclinical development and application of Nbs in AIDs are emphasized throughout this review.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信