miR-143/miR-223/miR4478 和 miR145 的异常表达是大肠癌患者的预后因素

IF 3.7 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of King Saud University - Science Pub Date : 2024-10-21 DOI:10.1016/j.jksus.2024.103494

Abdullah M Alhadheq , Rana Alhadheq , Saad Alkahtani

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引用次数: 0

摘要

大肠癌（CRC）是一种发生在结肠或直肠部位的恶性肿瘤。它是由于结肠内壁细胞异常生长和增殖而形成肿瘤。这项研究包括组织样本（56 个恶性样本和 56 个匹配的正常样本），从 miRBase 数据库测定和检索 miRNA，并通过 p53 基因进行调节。miRNA 的表达水平各不相同。mMiR-143、miR-4478和miR-145的表达量低于匹配的正常组织。只有 miR-143 和 miR-145 的表达在不同组间有相当大的差异，而 miR-4478 在统计学上没有表现出实质性差异。总之，这项研究强调了 P53 和 miR-223 的上调以及 miR-145 和 miR-143 的下调与沙特籍 CRC 患者的癌症进展和不良预后有关，这表明 P53、miR-223、miR-145 和 miR-143 是预测 CRC 患者预后的有价值的新特征。

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Aberrant expression of miR-143/miR-223/miR4478 and miR145 as prognostic factor for colorectal cancer patients

Colorectal cancer (CRC) is a type of malignancy that develops in the colon or rectal region. It develops due to abnormal growth and proliferation of cells in the lining of the colon, forming a tumor. This study included tissue samples (56 malignant and 56 matched normal samples). miRNAs were determined and retrieved from miRBase database and moderated by p53 gene. Expression levels of miRNA were varied. Only miR-223 revealed greater expression than normal matched tissue. mMiR-143, miR-4478, and miR-145 exhibited lower expression than matched normal tissue. Only miR-143 and miR-145 showed considerable variations in the expression among groups while miR-4478 did not demonstrate statistically substantial difference. In conclusion, this study highlights that upregulation of P53 and miR-223 and downregulation of miR-145 and miR-143 were associated with cancer advancement and unfavorable prognosis in Saudi CRC patients, indicating P53, miR-223, miR-145 and miR-143 to be novel and valuable signatures for predicting the outcomes for patients with CRC.

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来源期刊

Journal of King Saud University - Science Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

2.60%

发文量

642

审稿时长

49 days

期刊介绍： Journal of King Saud University – Science is an official refereed publication of King Saud University and the publishing services is provided by Elsevier. It publishes peer-reviewed research articles in the fields of physics, astronomy, mathematics, statistics, chemistry, biochemistry, earth sciences, life and environmental sciences on the basis of scientific originality and interdisciplinary interest. It is devoted primarily to research papers but short communications, reviews and book reviews are also included. The editorial board and associated editors, composed of prominent scientists from around the world, are representative of the disciplines covered by the journal.