激光诱导击穿光谱（LIBS）在生物医学分析中的应用

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2024-10-19 DOI:10.1016/j.trac.2024.117992

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引用次数: 0

摘要

生物系统中元素的微妙变化会直接影响新陈代谢和生理过程。快速准确地分析体内元素对临床疾病诊断至关重要。激光诱导击穿光谱（LIBS）因其快速、原位、微损伤等特点而得到广泛应用。本综述总结了2017-2024年LIBS在生物医学分析中的研究现状。首先介绍了LIBS的基础研究。根据研究对象的不同，将LIBS的生物医学应用分为微生物、生物组织和药用植物三大类。LIBS 在提高微生物病原体鉴定的准确性方面发挥着重要作用。在生物组织中，它可以揭示对生理分析和病理诊断至关重要的元素组成。对于药用植物，它侧重于检测重金属和掺假，以确保药品的安全性和真实性。最后，讨论了 LIBS 在生物医学领域的未来前景。

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Laser-induced breakdown spectroscopy (LIBS) in biomedical analysis

The subtle changes in elements within a biological system can directly impact metabolism and physiological processes. Rapid and accurate analysis of elements in the body is essential for clinical disease diagnosis. Laser-induced breakdown spectroscopy (LIBS) has been widely used because it is rapid, in-situ, and micro-damage. This review summarizes the research status of LIBS in biomedical analysis in 2017–2024. The basic research of LIBS is introduced initially. Based on the different research subjects, biomedical applications of LIBS are divided into three categories, namely, microorganisms, biological tissues, and medicinal plants. LIBS plays a crucial role in enhancing the accuracy of pathogen identification in microorganisms. In biological tissues, it reveals elemental compositions that are vital for physiological analysis and pathological diagnosis. For medicinal plants, it focuses on the detection of heavy metals and adulteration to ensure safety and authenticity of medicines. Finally, the future prospects of LIBS in biomedicine are discussed.

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.