Ir(III)催化的 N-亚氨基吡啶鎓酰化物与丙烯酸酯和炔烃的 C-H 烯化/annulation 反应

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2024-10-22 DOI:10.1016/j.tet.2024.134322

Xiaopei Chen , Zhiwei Ma , Chuanchuan Wang, Xuehui Hou, Juntao Liu

引用次数: 0

摘要

我们开发了一种简便高效的 Ir(III) 催化 N-iminopyridinium ylides 与丙烯酸酯和炔烃的正烯丙基化和环化反应方案，可提供邻烯丙基苯甲酰胺和异喹诺酮类化合物，收率从良好到极佳。该反应在外部无氧化剂条件下进行顺利，实用性强，效率高，对官能团的耐受性广。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ir(III)-catalyzed C–H alkenylation/annulation of N-iminopyridinium ylides with acrylates and alkynes

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Ir(III)-catalyzed C–H alkenylation/annulation of N-iminopyridinium ylides with acrylates and alkynes

A facile and efficient protocol for Ir(III)-catalyzed ortho-alkenylation and annulation of N-iminopyridinium ylides with acrylates and alkynes has been developed, providing o-alkenyl benzamides and isoquinolones in good to excellent yields. This reaction proceeds well under external oxidant free conditions with high practicality and efficiency, and broad functional group tolerance.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.