Study on the effect of the mixing method on particulate matter in compounded medication of insoluble β-lactam antibiotics: Simulation of biomedical heat transfer mechanism

The combination of insoluble β-lactam antibiotics has been widely used in clinical therapy, but its release in vivo and bioavailability remain challenges. This study aims to simulate the mechanism of biomedical heat transfer and analyze the influence of particulate matter in the combination of insoluble β-lactam antibiotics, so as to improve the therapeutic effectiveness of the drugs and optimize the clinical medication regimen. A mixed method was used to study the particulate matter of insoluble β-lactam antibiotics. In vitro simulation systems, combined with computational fluid dynamics (CFD) and heat conduction models, were used to evaluate drug release behavior in organisms. The physicochemical properties of the particles were determined and their heat transfer efficiency under different biomedical conditions was evaluated. The results showed that different types of particulate matter had significant effects on the release rate and bioavailability of β-lactam antibiotics. Simulations show that the optimized particle structure can significantly increase the local concentration of the drug and thus enhance the antibacterial effect under specific conditions of biomedical heat transfer. Through the simulation of the biomedical heat transfer mechanism of the mixed method, we can better understand the behavior of particles in the compound administration of insoluble β-lactam antibiotics, and explore the personalized medication strategy based on this mechanism.