营养充足对重症患者炎症、呼吸系统改善和机械通气断流成功率的影响：单盲随机对照临床试验

Q3 Nursing

Clinical Nutrition Open Science Pub Date : 2024-09-21 DOI:10.1016/j.nutos.2024.09.006

Hamideh mohammadi , Nafiseh Shokri-Mashhadi , Saeed Abbasi , Hossein Mahjobipoor , Maryam Eghbali Babadi

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引用次数: 0

摘要

背景这项前瞻性干预研究旨在通过多学科方法研究营养充足性对重症监护室住院患者呼吸机断流成功率的影响，研究中考虑了患者的基线营养状况并监测了营养测量结果。材料与方法在这项随机、单盲、双臂临床试验（IRCT20201229049876N1，注册日期：2021-01-06）中，受试者选自 2021 年 1 月至 2022 年 6 月期间在三家医疗中心的重症监护病房（ICU）接受机械通气治疗的患者。结果我们的研究结果显示，与对照组62%的患者相比，干预组92%的患者每日能量摄入量更高（≥目标千卡的80%）（P≤0.05）。研究结束时，两组患者的体重指数和呼吸功能参数值无明显差异（P> 0.1）。结论应用多学科营养支持计划可改善 ICU 通气患者的营养充足性、CRP 水平和 BWAP 评分。

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Effect of nutrition adequacy on inflammation, respiratory improvement, and success of weaning from mechanical ventilation in critically ill patients: A single-blind randomized controlled clinical trial

Background

This prospective interventional study aimed to investigate the effect of nutritional adequacy through a multidisciplinary approach on the success of ventilator weaning in patients admitted to ICU considering patients' nutritional status at baseline and monitoring nutritional measurements during the study.

Materials and methods

In this randomized, single-blind, two-arm clinical trial (IRCT20201229049876N1, Registration date: 2021-01-06), subjects were selected from patients undergoing mechanical ventilation and admitted to the intensive care unit (ICU) of three medical centers between January 2021 and June 2022. The intervention group received multidisciplinary nutritional support rounds twice weekly, while the control group received the usual nutrition therapy (physician-centered NS).

Results

Our results showed that 92% of patients in the intervention group had a higher daily energy intake (≥80% of goal Kcal) compared with the control group, 62% of patients (P≤ 0.05). There were no significant differences in terms of BMI, and values of respiratory function parameters between the two groups (all P> 0.1) at the end of the study. However, the mean score of the Burns Wean Assessment Program (BWAP), and circulating levels of C-reactive protein were significantly changed in the interventional group than in the control group.