温度增强的非费克式扩散

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
José A. Ferreira , Mario Grassi , Elías Gudiño , Paula de Oliveira
{"title":"温度增强的非费克式扩散","authors":"José A. Ferreira ,&nbsp;Mario Grassi ,&nbsp;Elías Gudiño ,&nbsp;Paula de Oliveira","doi":"10.1016/j.cam.2024.116314","DOIUrl":null,"url":null,"abstract":"<div><div>In this paper we present a novel mathematical model to describe the permeation of a fluid through a polymeric matrix, loaded with drug molecules, followed by its subsequent desorption. Both phenomena are enhanced by temperature. We deduce energy estimates and stability estimates for the weak solution of the model, showing that this solution of the problem is stable in bounded time intervals. Numerical simulations illustrate how the coupling effects, of viscoelastic properties and thermal external assistance, can have a central role in the design of drug delivery devices.</div></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-Fickian diffusion enhanced by temperature\",\"authors\":\"José A. Ferreira ,&nbsp;Mario Grassi ,&nbsp;Elías Gudiño ,&nbsp;Paula de Oliveira\",\"doi\":\"10.1016/j.cam.2024.116314\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In this paper we present a novel mathematical model to describe the permeation of a fluid through a polymeric matrix, loaded with drug molecules, followed by its subsequent desorption. Both phenomena are enhanced by temperature. We deduce energy estimates and stability estimates for the weak solution of the model, showing that this solution of the problem is stable in bounded time intervals. Numerical simulations illustrate how the coupling effects, of viscoelastic properties and thermal external assistance, can have a central role in the design of drug delivery devices.</div></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0377042724005624\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"100","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0377042724005624","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

摘要

在本文中,我们提出了一个新颖的数学模型,用于描述液体通过装有药物分子的聚合物基质的渗透及其随后的解吸。这两种现象都会受到温度的影响。我们推导出该模型弱解的能量估计值和稳定性估计值,表明该问题解在有界时间间隔内是稳定的。数值模拟说明了粘弹性和热外力的耦合效应如何在给药装置的设计中发挥核心作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-Fickian diffusion enhanced by temperature
In this paper we present a novel mathematical model to describe the permeation of a fluid through a polymeric matrix, loaded with drug molecules, followed by its subsequent desorption. Both phenomena are enhanced by temperature. We deduce energy estimates and stability estimates for the weak solution of the model, showing that this solution of the problem is stable in bounded time intervals. Numerical simulations illustrate how the coupling effects, of viscoelastic properties and thermal external assistance, can have a central role in the design of drug delivery devices.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信