{"title":"姜黄作为一种治疗剂，可防止砷诱导的大鼠模型代谢失调","authors":"Adewale Adetutu , Abiodun Bukunmi Aborisade , Temitope Deborah Olaniyi","doi":"10.1016/j.prenap.2024.100110","DOIUrl":null,"url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><div>Health hazards stemming from metalloid consumption, such as arsenic, pose a global concern. This study aimed to assess the protective effects of turmeric against arsenic-induced alterations in lipid profiles and energy metabolism in rats.</div></div><div><h3>Methods</h3><div>Thirty male rats were divided into three groups over a 90–180-day exposure period: Group 1 (Control) received standard rat chow; Group 2 received an arsenic diet; and Group 3 received arsenic plus turmeric supplemented diet. Blood and liver tissue samples were collected for lipid profiles, glucose levels, energy metabolism parameters, and PPAR-α mRNA expression using qRT-PCR. Statistical analysis was performed (p<0.05).</div></div><div><h3>Results</h3><div>Results indicated significant (p<0.05) increases in lipid profiles among arsenic-exposed rats after 180 days, elevating the risk of coronary artery diseases. Both arsenic and turmeric-exposed groups showed heightened total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL) levels at 90 and 180 days, with nuanced differences suggesting dyslipidemia and atherosclerosis. Blood glucose observations revealed hypoglycemia initially in arsenic-exposed rats, progressing to hyperglycemia by 180 days. Arsenic significantly (p<0.05) inhibited pyruvate kinase, hexokinase, and isocitrate dehydrogenase activities in the liver after 180 days, while turmeric exposure showed no significant (p<0.05) changes. Additionally, both arsenic and turmeric groups exhibited downregulation of PPAR-α expression at 180 days. In-silico analysis identified curcumin as a promising component for anti-atherosclerosis and arsenic-related conditions due to its strong binding affinities and multiple hydrogen bond formations.</div></div><div><h3>Conclusion</h3><div>In conclusion, long-term turmeric consumption may mitigate arsenic-induced oxidative damage associated with early hyperglycemia, diabetes mellitus, cardiovascular diseases, and atherosclerosis. These findings underscore turmeric’s potential therapeutic role against arsenic toxicity, suggesting avenues for future research and public health interventions.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100110"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Turmeric as a therapeutic agent against arsenic-induced metabolic dysregulation in rat models\",\"authors\":\"Adewale Adetutu , Abiodun Bukunmi Aborisade , Temitope Deborah Olaniyi\",\"doi\":\"10.1016/j.prenap.2024.100110\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Ethnopharmacological relevance</h3><div>Health hazards stemming from metalloid consumption, such as arsenic, pose a global concern. This study aimed to assess the protective effects of turmeric against arsenic-induced alterations in lipid profiles and energy metabolism in rats.</div></div><div><h3>Methods</h3><div>Thirty male rats were divided into three groups over a 90–180-day exposure period: Group 1 (Control) received standard rat chow; Group 2 received an arsenic diet; and Group 3 received arsenic plus turmeric supplemented diet. Blood and liver tissue samples were collected for lipid profiles, glucose levels, energy metabolism parameters, and PPAR-α mRNA expression using qRT-PCR. Statistical analysis was performed (p<0.05).</div></div><div><h3>Results</h3><div>Results indicated significant (p<0.05) increases in lipid profiles among arsenic-exposed rats after 180 days, elevating the risk of coronary artery diseases. Both arsenic and turmeric-exposed groups showed heightened total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL) levels at 90 and 180 days, with nuanced differences suggesting dyslipidemia and atherosclerosis. Blood glucose observations revealed hypoglycemia initially in arsenic-exposed rats, progressing to hyperglycemia by 180 days. Arsenic significantly (p<0.05) inhibited pyruvate kinase, hexokinase, and isocitrate dehydrogenase activities in the liver after 180 days, while turmeric exposure showed no significant (p<0.05) changes. Additionally, both arsenic and turmeric groups exhibited downregulation of PPAR-α expression at 180 days. In-silico analysis identified curcumin as a promising component for anti-atherosclerosis and arsenic-related conditions due to its strong binding affinities and multiple hydrogen bond formations.</div></div><div><h3>Conclusion</h3><div>In conclusion, long-term turmeric consumption may mitigate arsenic-induced oxidative damage associated with early hyperglycemia, diabetes mellitus, cardiovascular diseases, and atherosclerosis. These findings underscore turmeric’s potential therapeutic role against arsenic toxicity, suggesting avenues for future research and public health interventions.</div></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"5 \",\"pages\":\"Article 100110\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199724000983\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199724000983","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Turmeric as a therapeutic agent against arsenic-induced metabolic dysregulation in rat models
Ethnopharmacological relevance
Health hazards stemming from metalloid consumption, such as arsenic, pose a global concern. This study aimed to assess the protective effects of turmeric against arsenic-induced alterations in lipid profiles and energy metabolism in rats.
Methods
Thirty male rats were divided into three groups over a 90–180-day exposure period: Group 1 (Control) received standard rat chow; Group 2 received an arsenic diet; and Group 3 received arsenic plus turmeric supplemented diet. Blood and liver tissue samples were collected for lipid profiles, glucose levels, energy metabolism parameters, and PPAR-α mRNA expression using qRT-PCR. Statistical analysis was performed (p<0.05).
Results
Results indicated significant (p<0.05) increases in lipid profiles among arsenic-exposed rats after 180 days, elevating the risk of coronary artery diseases. Both arsenic and turmeric-exposed groups showed heightened total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL) levels at 90 and 180 days, with nuanced differences suggesting dyslipidemia and atherosclerosis. Blood glucose observations revealed hypoglycemia initially in arsenic-exposed rats, progressing to hyperglycemia by 180 days. Arsenic significantly (p<0.05) inhibited pyruvate kinase, hexokinase, and isocitrate dehydrogenase activities in the liver after 180 days, while turmeric exposure showed no significant (p<0.05) changes. Additionally, both arsenic and turmeric groups exhibited downregulation of PPAR-α expression at 180 days. In-silico analysis identified curcumin as a promising component for anti-atherosclerosis and arsenic-related conditions due to its strong binding affinities and multiple hydrogen bond formations.
Conclusion
In conclusion, long-term turmeric consumption may mitigate arsenic-induced oxidative damage associated with early hyperglycemia, diabetes mellitus, cardiovascular diseases, and atherosclerosis. These findings underscore turmeric’s potential therapeutic role against arsenic toxicity, suggesting avenues for future research and public health interventions.
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