100（PB088）：KRAS 多种抑制剂 BI 3706674 在 KRAS 驱动的癌症临床前模型中显示出疗效，支持对携带 KRASG12V 突变和 KRAS 野生型扩增的肿瘤患者进行临床试验。

{"title":"100（PB088）：KRAS 多种抑制剂 BI 3706674 在 KRAS 驱动的癌症临床前模型中显示出疗效，支持对携带 KRASG12V 突变和 KRAS 野生型扩增的肿瘤患者进行临床试验。","authors":"A. Tedeschi, D.H. Peng, F. Schischlik-Siegl, O. Schaaf, D. Gerlach, F. Rocchetti, J. Popow, J. Broeker, T. Wunberg, A.S. Boghossian, M.G. Rees, M.M. Ronan, J.A. Roth, M. Williams, C. Vellano, J.R. Marszalek, T.P. Heffernan, M. Pearson, N. Kraut, R. Dorothea","doi":"10.1016/j.ejca.2024.114624","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"211 ","pages":"Article 114624"},"PeriodicalIF":7.6000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"100 (PB088): KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications.\",\"authors\":\"A. Tedeschi, D.H. Peng, F. Schischlik-Siegl, O. Schaaf, D. Gerlach, F. Rocchetti, J. Popow, J. Broeker, T. Wunberg, A.S. Boghossian, M.G. Rees, M.M. Ronan, J.A. Roth, M. Williams, C. Vellano, J.R. Marszalek, T.P. Heffernan, M. Pearson, N. Kraut, R. Dorothea\",\"doi\":\"10.1016/j.ejca.2024.114624\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":11980,\"journal\":{\"name\":\"European Journal of Cancer\",\"volume\":\"211 \",\"pages\":\"Article 114624\"},\"PeriodicalIF\":7.6000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0959804924013157\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959804924013157","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}