不稳定性是镰状细胞病儿童抑郁的一个独立风险因素

IF 4.7 2区 医学 Q1 PSYCHIATRY
Narcisse Elenga, Janaine Lony, Joddy Mafemamissindu, Noelis Thomas Boizan, Lindsay Osei, Mathieu Nacher
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引用次数: 0

摘要

重要性:虽然抑郁症在镰状细胞病中的发病率和影响已被广泛描述,但其与不稳定性的关系却从未被研究过。 研究目的本研究旨在描述法属圭亚那镰状细胞病儿童中抑郁症的患病率及其与临床和人口学因素(包括社会不稳定因素)的关系。 研究方法我们纳入了法属圭亚那镰状细胞参考中心的 12-18 岁镰状细胞病患儿。我们提出了一份简单的抑郁问卷 "儿童抑郁量表 2",并通过临床检查和心理学家咨询完成了问卷。利用已知的健康筛查中心健康不平等和贫困评估(EPICES)评分,我们制定了一个综合不稳定评分,其中包括五个项目(每个项目的评分范围为 0 至 2)。根据所选项目,得分≥5 分即为不稳定。 结果显示抑郁症患病率为 42.5% [95% CI:31.5-54]。年龄中位数为 15 岁 [95% CI:13-17]。抑郁症患者的年龄分布在 14 岁时达到高峰。在抑郁组中,76%的患者病情不稳定,而在对照组中,18%的患者病情不稳定(p <0.0001)。在多变量分析中,基因型 SC(OR = 7.66,[1.17; 50.13],p = 0.0338)和不稳定(OR = 15.68,[4.73; 51.94],p < 0.0001)与较高的抑郁症发病率相关。基线血红蛋白水平(OR = 0.48, [0.27; 0.88], p = 0.0173)也与较低的抑郁率有关。 结论与意义:尽管有免费的医疗保健,但不稳定是抑郁症的一个独立风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Precariousness Represents an Independent Risk Factor for Depression in Children With Sickle Cell Disease

Precariousness Represents an Independent Risk Factor for Depression in Children With Sickle Cell Disease

Importance: While the prevalence and impact of depression have been widely described in sickle cell disease, its relationship with precariousness has never been studied.

Objective: This study aimed to describe the prevalence of depression and its relationship with clinical and demographic factors including social precariousness in children with sickle cell disease in French Guiana.

Methods: We included children aged 12–18 years with sickle cell disease from the Sickle Cell Reference Center in French Guiana. A simple depression questionnaire “Child depression inventory 2” was proposed and completed by a clinical examination and consultation by a psychologist. Using the known assessment of health inequalities and poverty in health screening centres (EPICES) score, we developed a composite precariousness score that uses five items (each item is scored from 0 to 2). According to the chosen items, precariousness was defined as a score ≥5.

Results: The prevalence of depression was 42.5% [95% CI: 31.5–54]. The median age was 15 years [95% CI: 13–17]. The age distribution peaked at 14 years in patients with depression. There were 76% of precarious patients in the depressed group and 18% in the control group (p  < 0.0001). In multivariate analysis, genotype SC (OR = 7.66, [1.17; 50.13], p = 0.0338) and precariousness (OR = 15.68, [4.73; 51.94], p  < 0.0001) were associated with higher rates of depression. Baseline hemoglobin levels (OR = 0.48, [0.27; 0.88], p = 0.0173) were also associated with lower rates of depression.

Conclusions and Relevance: Despite free healthcare, precariousness is an independent risk factor for depression.

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来源期刊
Depression and Anxiety
Depression and Anxiety 医学-精神病学
CiteScore
15.00
自引率
1.40%
发文量
81
审稿时长
4-8 weeks
期刊介绍: Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.
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