藻酸盐-半胱氨酸共轭物:天然抗菌水凝胶

IF 2.6 4区 化学 Q3 POLYMER SCIENCE
Tatiane Araujo Soares, André Henrique Furtado Torres, Bruna Carolina Dorm, André Capaldo Amaral, Tamires de Souza Nossa, Eliane Trovatti
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引用次数: 0

摘要

微生物感染在全球范围内蔓延是一个具有挑战性的问题,在食品和卫生领域需要引起高度重视。为减少或避免细菌感染而开发新型生物材料的研究日益增多,天然聚合物已成为一些研究的重点。藻酸盐是一种丰富的天然聚合物,根据其化学结构,有可能进行化学改性,但就我们所知,还没有人对其进行过抗菌改性。本研究旨在通过对海藻酸盐进行半胱氨酸化学修饰,制备一种新的生物材料,目的是推断所制备材料的内在抗菌活性,以及通过二硫键的形成实现原位凝胶能力。聚合物的表征方法包括傅立叶变换红外光谱、核磁共振、热分析、交联测试、流变分析、水解降解、微生物测试(针对大肠杆菌和金黄色葡萄球菌)和细胞毒性。傅立叶变换红外光谱(FTIR)和核磁共振(NMR)显示的化学特征结果表明,反应成功,由于材料的交联,海藻酸-Cys 的粘度增加。研究结果表明,藻酸盐-Cys 对所研究的细菌无毒性并具有抗菌活性,这表明它们具有开发应用于糖果和医疗设备涂层材料的潜力,目的是减少或避免感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alginate-cysteine conjugate: antimicrobial hydrogel from natural source

Microbial infections spreading represents a challenging scenario worldwide, with remarkable demand for attention in food and heath fields. An increase in studies for the development of new biomaterials with the aim of decreasing or avoiding bacterial infections has been arising, and the natural polymers have been the focus of some studies. Alginate is an abundant natural polymer with potential for chemical modifications based on its chemical structure and, to the best of our knowledge, it was not modified for antimicrobial activity. This study aims to prepare a new biomaterial by chemical modification of alginate coupled with the cysteine, aiming to infer intrinsic antimicrobial activity to the resulting material, and also, situ gelation capability by the formation of disulfide bonds. The polymers were characterized by FTIR, NMR, thermal analysis, cross-linking test, rheological analysis, hydrolytic degradation, microbiological test (against E. coli and S. aureus) and cytotoxicity. The results of the chemical characterization, as evidenced by FTIR and NMR, indicated the success of the reaction and the increase in the viscosity of alginate-Cys due to the cross-linking of the material. The results showed no toxicity and demonstrated antimicrobial activity against the studied bacteria, indicating their potential for the development of materials for applications in the confection and coating of medical devices, aiming to decrease or avoid infections.

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来源期刊
Journal of Polymer Research
Journal of Polymer Research 化学-高分子科学
CiteScore
4.70
自引率
7.10%
发文量
472
审稿时长
3.6 months
期刊介绍: Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.
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