藻酸盐-半胱氨酸共轭物:天然抗菌水凝胶

IF 2.6 4区 化学 Q3 POLYMER SCIENCE
Tatiane Araujo Soares, André Henrique Furtado Torres, Bruna Carolina Dorm, André Capaldo Amaral, Tamires de Souza Nossa, Eliane Trovatti
{"title":"藻酸盐-半胱氨酸共轭物:天然抗菌水凝胶","authors":"Tatiane Araujo Soares,&nbsp;André Henrique Furtado Torres,&nbsp;Bruna Carolina Dorm,&nbsp;André Capaldo Amaral,&nbsp;Tamires de Souza Nossa,&nbsp;Eliane Trovatti","doi":"10.1007/s10965-024-04178-y","DOIUrl":null,"url":null,"abstract":"<p>Microbial infections spreading represents a challenging scenario worldwide, with remarkable demand for attention in food and heath fields. An increase in studies for the development of new biomaterials with the aim of decreasing or avoiding bacterial infections has been arising, and the natural polymers have been the focus of some studies. Alginate is an abundant natural polymer with potential for chemical modifications based on its chemical structure and, to the best of our knowledge, it was not modified for antimicrobial activity. This study aims to prepare a new biomaterial by chemical modification of alginate coupled with the cysteine, aiming to infer intrinsic antimicrobial activity to the resulting material, and also, situ gelation capability by the formation of disulfide bonds. The polymers were characterized by FTIR, NMR, thermal analysis, cross-linking test, rheological analysis, hydrolytic degradation, microbiological test (against <i>E. coli and S. aureus</i>) and cytotoxicity. The results of the chemical characterization, as evidenced by FTIR and NMR, indicated the success of the reaction and the increase in the viscosity of alginate-Cys due to the cross-linking of the material. The results showed no toxicity and demonstrated antimicrobial activity against the studied bacteria, indicating their potential for the development of materials for applications in the confection and coating of medical devices, aiming to decrease or avoid infections.</p>","PeriodicalId":658,"journal":{"name":"Journal of Polymer Research","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Alginate-cysteine conjugate: antimicrobial hydrogel from natural source\",\"authors\":\"Tatiane Araujo Soares,&nbsp;André Henrique Furtado Torres,&nbsp;Bruna Carolina Dorm,&nbsp;André Capaldo Amaral,&nbsp;Tamires de Souza Nossa,&nbsp;Eliane Trovatti\",\"doi\":\"10.1007/s10965-024-04178-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Microbial infections spreading represents a challenging scenario worldwide, with remarkable demand for attention in food and heath fields. An increase in studies for the development of new biomaterials with the aim of decreasing or avoiding bacterial infections has been arising, and the natural polymers have been the focus of some studies. Alginate is an abundant natural polymer with potential for chemical modifications based on its chemical structure and, to the best of our knowledge, it was not modified for antimicrobial activity. This study aims to prepare a new biomaterial by chemical modification of alginate coupled with the cysteine, aiming to infer intrinsic antimicrobial activity to the resulting material, and also, situ gelation capability by the formation of disulfide bonds. The polymers were characterized by FTIR, NMR, thermal analysis, cross-linking test, rheological analysis, hydrolytic degradation, microbiological test (against <i>E. coli and S. aureus</i>) and cytotoxicity. The results of the chemical characterization, as evidenced by FTIR and NMR, indicated the success of the reaction and the increase in the viscosity of alginate-Cys due to the cross-linking of the material. The results showed no toxicity and demonstrated antimicrobial activity against the studied bacteria, indicating their potential for the development of materials for applications in the confection and coating of medical devices, aiming to decrease or avoid infections.</p>\",\"PeriodicalId\":658,\"journal\":{\"name\":\"Journal of Polymer Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Polymer Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10965-024-04178-y\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymer Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10965-024-04178-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0

摘要

微生物感染在全球范围内蔓延是一个具有挑战性的问题,在食品和卫生领域需要引起高度重视。为减少或避免细菌感染而开发新型生物材料的研究日益增多,天然聚合物已成为一些研究的重点。藻酸盐是一种丰富的天然聚合物,根据其化学结构,有可能进行化学改性,但就我们所知,还没有人对其进行过抗菌改性。本研究旨在通过对海藻酸盐进行半胱氨酸化学修饰,制备一种新的生物材料,目的是推断所制备材料的内在抗菌活性,以及通过二硫键的形成实现原位凝胶能力。聚合物的表征方法包括傅立叶变换红外光谱、核磁共振、热分析、交联测试、流变分析、水解降解、微生物测试(针对大肠杆菌和金黄色葡萄球菌)和细胞毒性。傅立叶变换红外光谱(FTIR)和核磁共振(NMR)显示的化学特征结果表明,反应成功,由于材料的交联,海藻酸-Cys 的粘度增加。研究结果表明,藻酸盐-Cys 对所研究的细菌无毒性并具有抗菌活性,这表明它们具有开发应用于糖果和医疗设备涂层材料的潜力,目的是减少或避免感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alginate-cysteine conjugate: antimicrobial hydrogel from natural source

Microbial infections spreading represents a challenging scenario worldwide, with remarkable demand for attention in food and heath fields. An increase in studies for the development of new biomaterials with the aim of decreasing or avoiding bacterial infections has been arising, and the natural polymers have been the focus of some studies. Alginate is an abundant natural polymer with potential for chemical modifications based on its chemical structure and, to the best of our knowledge, it was not modified for antimicrobial activity. This study aims to prepare a new biomaterial by chemical modification of alginate coupled with the cysteine, aiming to infer intrinsic antimicrobial activity to the resulting material, and also, situ gelation capability by the formation of disulfide bonds. The polymers were characterized by FTIR, NMR, thermal analysis, cross-linking test, rheological analysis, hydrolytic degradation, microbiological test (against E. coli and S. aureus) and cytotoxicity. The results of the chemical characterization, as evidenced by FTIR and NMR, indicated the success of the reaction and the increase in the viscosity of alginate-Cys due to the cross-linking of the material. The results showed no toxicity and demonstrated antimicrobial activity against the studied bacteria, indicating their potential for the development of materials for applications in the confection and coating of medical devices, aiming to decrease or avoid infections.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Polymer Research
Journal of Polymer Research 化学-高分子科学
CiteScore
4.70
自引率
7.10%
发文量
472
审稿时长
3.6 months
期刊介绍: Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信