被误诊为肺结核患者的高死亡率：对巴西被诊断为肺结核患者的匹配回顾性队列研究。

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI:10.1093/infdis/jiae531

Ryan R Thompson, Sun Kim, Daniele Maria Pelissari, Luiza Ohana Harada, José Nildo de Barros Silva, Patricia Bartholomay Oliveira, Marcia C Castro, Ted Cohen, Nicolas A Menzies

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引用次数: 0

摘要

我们开展了一项匹配的回顾性队列研究，比较了 2007-2016 年巴西结核病假阳性诊断患者（3701 人）与结核病正确诊断患者（8595 人）的死亡率。在平均 5.4 年的随访期内，我们估计与对照组相比，被误诊为肺结核患者的死亡率比为 1.95（95% 置信区间：1.80, 2.11）。误诊患者的主要死因是恶性肿瘤（40.9%）和呼吸系统疾病（15.9%），这些疾病的症状与肺结核相似。我们的研究结果突出表明，在发现假阳性病例后，有必要改善后续护理，以提高这一高风险人群的存活率。

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High Mortality Rates Among Individuals Misdiagnosed With Tuberculosis: A Matched Retrospective Cohort Study of Individuals Diagnosed With Tuberculosis in Brazil.

We conducted a matched retrospective cohort study comparing mortality among individuals receiving a false-positive tuberculosis (TB) diagnosis (n = 3701) to individuals correctly diagnosed with TB (n = 8595) in Brazil from 2007 to 2016. Over an average 5.4-year follow-up period, we estimated a mortality rate ratio of 1.95 (95% confidence interval, 1.80-2.11) for individuals incorrectly diagnosed with TB compared to controls. The leading causes of death among the misdiagnosed were malignant neoplasms (40.9%) and respiratory system disorders (15.9%), conditions with symptoms similar to TB. Our findings highlight the need for improved follow-up care after identification of false-positive cases to increase survival for this high-risk population.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.