细胞外囊泡在肥胖症生理作用方面的不足、局限和差距。

IF 4.7 2区 医学 Q1 NEUROSCIENCES
Paola Valero, Katherin Silva, Andrés Valenzuela-Hinrichsen, Antonia Vásquez, Fernanda Espinoza, Fernanda Lira, Marcelo Cornejo, Gonzalo Fuentes, Daniel González, Rodrigo Moore-Carrasco, Eline M van der Beek, Jan-Luuk Hillebrands, Harry van Goor, Adriana Grismaldo, Luis Sobrevia
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引用次数: 0

摘要

细胞外囊泡(EVs)在介导跨物种和跨王国的细胞间交流方面发挥着至关重要的作用。细胞外囊泡通过自分泌和旁分泌信号机制促进的细胞间通讯对于细胞存活、维持正常代谢功能以及确保整体身体平衡和健康至关重要。细胞外囊泡存在于各种体液中,如胸腔积液、血浆、母乳、羊水、精液和唾液。此外,EVs 的产生和释放有助于清除细胞废物。与体重正常的人相比,肥胖症患者的循环 EVs 释放量和数量更高。肥胖症患者体内 EVs 释放量的增加可能会导致这种新陈代谢状况所特有的炎症状态,因为在 EVs 货物中发现了更高水平的促炎症分子。然而,解读有关 EV 丰度、货物和生物作用的结果可能会因多种因素而变得复杂;这些因素包括细胞来源的变化、年龄范围(从儿童到老人)、男女混合、药物使用和健康状况、体重范围(从正常体重到病态肥胖)以及使用细胞系与原代培养物的体外检测之间的差异。这篇文章探讨了相关知识的不足、局限和差距,为我们进一步了解 EVs 对肥胖的生理影响提供了一个框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Shortcomings, limitations and gaps in physiological roles of extracellular vesicles in obesity.

Extracellular vesicles (EVs) play a crucial role in mediating communication between cells across species and kingdoms. The intercellular communication facilitated by EVs through autocrine and paracrine signalling mechanisms is essential for cell survival, maintaining normal metabolic functions and ensuring overall bodily homeostasis and health. Extracellular vesicles are present in various bodily fluids, such as pleural effusions, plasma, breast milk, amniotic fluid, semen and saliva. Additionally, the generation and release of EVs contribute to the removal of cellular waste. Patients with obesity exhibit a higher release and amount of circulating EVs than individuals with normal weight. This increased EV release in obesity might contribute to the inflammatory state characteristic of this metabolic condition, because higher levels of pro-inflammatory molecules are found within their cargo. However, interpreting results related to EV abundance, cargo and biological actions can be complicated by several factors; these include variations in cell sources, a wide age range (from children to the elderly), a mix of females and males, medication use and health status, a range of body weights (from normal weight to morbid obesity) and differences between in vitro assays using cell lines versus primary cultures. This article addresses the shortcomings, limitations and gaps in knowledge, providing a framework for enhancing our understanding of the physiological effects of EVs on obesity.

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来源期刊
Journal of Physiology-London
Journal of Physiology-London 医学-神经科学
CiteScore
9.70
自引率
7.30%
发文量
817
审稿时长
2 months
期刊介绍: The Journal of Physiology publishes full-length original Research Papers and Techniques for Physiology, which are short papers aimed at disseminating new techniques for physiological research. Articles solicited by the Editorial Board include Perspectives, Symposium Reports and Topical Reviews, which highlight areas of special physiological interest. CrossTalk articles are short editorial-style invited articles framing a debate between experts in the field on controversial topics. Letters to the Editor and Journal Club articles are also published. All categories of papers are subjected to peer reivew. The Journal of Physiology welcomes submitted research papers in all areas of physiology. Authors should present original work that illustrates new physiological principles or mechanisms. Papers on work at the molecular level, at the level of the cell membrane, single cells, tissues or organs and on systems physiology are all acceptable. Theoretical papers and papers that use computational models to further our understanding of physiological processes will be considered if based on experimentally derived data and if the hypothesis advanced is directly amenable to experimental testing. While emphasis is on human and mammalian physiology, work on lower vertebrate or invertebrate preparations may be suitable if it furthers the understanding of the functioning of other organisms including mammals.
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