钙稳态调节器家族的生物学、功能和结构。

IF 4.7 2区医学 Q1 NEUROSCIENCES

Journal of Physiology-London Pub Date : 2024-10-29 DOI:10.1113/JP285197

Rachel Polfer, Hiro Furukawa

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引用次数: 0

摘要

钙稳态调节器（CALHMs）是最近发现的大孔通道家族成员。它们介导离子和较大分子（如 ATP）的传导，在与阿尔茨海默病、神经炎症、神经调节、味觉感知和先天性免疫反应有关的通路中发挥着关键作用。自 2008 年首次报道 CALHM1 以来，有关其生物学作用、离子和 ATP 通道功能及结构的研究取得了重大突破，为该领域的进一步发展奠定了基础。在这篇综述中，我们将讨论在了解 CALHM 蛋白的生物学作用、功能和分子结构方面的总体进展和最新发展。

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Biology, function and structure of the calcium homeostasis modulator family.

Calcium homeostasis modulators (CALHMs) are the most recently discovered members of the large-pore channel family. They mediate the conductance of ions and larger molecules, such as ATP, and play critical roles in pathways related to Alzheimer's disease, neuroinflammation, neuromodulation, taste perception and innate immune responses. Since the inaugural report on CALHM1 in 2008, significant breakthroughs have revealed their biological roles, ion and ATP channel functions, and structures, positioning the field for further advancements. In this review, we discuss the overall progress and recent developments in understanding the biological roles, functions and molecular structures of CALHM proteins.

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来源期刊

Journal of Physiology-London 医学-神经科学

CiteScore

9.70

自引率

7.30%

发文量

817

审稿时长

2 months

期刊介绍： The Journal of Physiology publishes full-length original Research Papers and Techniques for Physiology, which are short papers aimed at disseminating new techniques for physiological research. Articles solicited by the Editorial Board include Perspectives, Symposium Reports and Topical Reviews, which highlight areas of special physiological interest. CrossTalk articles are short editorial-style invited articles framing a debate between experts in the field on controversial topics. Letters to the Editor and Journal Club articles are also published. All categories of papers are subjected to peer reivew. The Journal of Physiology welcomes submitted research papers in all areas of physiology. Authors should present original work that illustrates new physiological principles or mechanisms. Papers on work at the molecular level, at the level of the cell membrane, single cells, tissues or organs and on systems physiology are all acceptable. Theoretical papers and papers that use computational models to further our understanding of physiological processes will be considered if based on experimentally derived data and if the hypothesis advanced is directly amenable to experimental testing. While emphasis is on human and mammalian physiology, work on lower vertebrate or invertebrate preparations may be suitable if it furthers the understanding of the functioning of other organisms including mammals.