代谢中的组蛋白去乙酰化酶：已知与未知。

IF 5.3 2区医学 Q1 PHYSIOLOGY

Physiology Pub Date : 2024-10-29 DOI:10.1152/physiol.00044.2024

Somaya Y Ibrahim, Jayden Carter, Rushita A Bagchi

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引用次数: 0

摘要

组蛋白去乙酰化酶（HDACs）是一种催化去除组蛋白和非组蛋白上关键赖氨酸残基上乙酰基从而调节基因转录的酶。它们与健康和病理环境中的多个生物过程都有关联。本综述讨论了 HDACs 在多种代谢活跃组织中的作用，并强调了它们对组织特异性适应不良和疾病发病机制的贡献。我们还总结了目前的知识空白以及在未来研究中解决这些问题的潜在方法。

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Histone Deacetylases in Metabolism: The Known and the Unexplored.

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from key lysine residues on histone and non-histone proteins and thereby regulate gene transcription. They have been implicated in several biological processes in both healthy and pathologic settings. This review discusses the role of HDACs in multiple metabolically active tissues and highlights their contribution to the pathogenesis of tissue-specific maladaptation and diseases. We also summarize the current knowledge gaps and potential ways to address them in future studies.

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来源期刊

Physiology 医学-生理学

CiteScore

14.50

自引率

0.00%

发文量

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