SCUBA-D：新训练的扩散模型生成高质量的蛋白质结构。

IF 36.1 1区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Nature Methods Pub Date : 2024-10-28 DOI:10.1038/s41592-024-02465-6

引用次数: 0

摘要

SCUBA-D是一个独立训练的蛋白质骨架结构扩散模型，与现有的蛋白质结构预测网络正交，16个设计蛋白质和一个蛋白质复合物的X射线结构以及设计血红素结合蛋白和Ras结合蛋白的实验验证证实了SCUBA-D的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

SCUBA-D: a freshly trained diffusion model generates high-quality protein structures

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SCUBA-D: a freshly trained diffusion model generates high-quality protein structures

The accuracy of SCUBA-D, a protein backbone structure diffusion model trained independently and orthogonally to existing protein structure prediction networks, is confirmed by the X-ray structures of 16 designed proteins and a protein complex, and by experimental validation of designed heme-binding proteins and Ras-binding proteins.

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来源期刊

Nature Methods 生物-生化研究方法

CiteScore

58.70

自引率

1.70%

发文量

326

审稿时长

1 months

期刊介绍： Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.