替诺福韦-阿米布非那胺和替诺福韦-阿拉非那胺治疗首次出现的 HBV 相关失代偿性肝硬化的有效性和安全性。

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Xinxin Rong, Guangde Yang, Yuanyuan Xu, He Chen, Xia Wang, Juanjuan Fu, Li Li, Xiucheng Pan
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引用次数: 0

摘要

关于替诺福韦-阿米布非那胺(TMF)和替诺福韦-阿拉非那胺(TAF)治疗 HBV 相关失代偿性肝硬化(HBV-DC)患者的临床研究非常有限。本研究评估了TMF与TAF对首次接受治疗的HBV-DC患者的疗效和安全性。根据所使用的抗病毒药物,患者被分为 TMF 组和 TAF 组。在 48 周的治疗期间,对两组患者的病毒学和血清学反应、肝肾功能和血脂变化进行评估。共有 98 名患者入组,其中 TMF 组 45 人,TAF 组 53 人。治疗 48 周时,获得完全病毒学应答(CVR)的患者比例分别为 85.7% 和 90.7%(P = 0.791)。64.3% 和 79.1% 的患者的 Child-Turcotte-Pugh 评分至少提高了 2 分(p = 0.169)。从基线到第 48 周,两组患者的血清肌酐、估计肾小球滤过率或总胆固醇均无明显变化。胱抑素 C 在 TMF 组保持稳定,但在 TAF 组则随着时间的推移而增加(p = 0.169)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and Safety of Tenofovir Amibufenamide and Tenofovir Alafenamide for First-Time HBV-Related Decompensated Cirrhosis.

Clinical studies of tenofovir amibufenamide (TMF) and tenofovir alafenamide (TAF) treatment in patients with HBV-related decompensated cirrhosis (HBV-DC) are limited. This study evaluated the efficacy and safety of TMF versus TAF in naive-treated patients with first-time HBV-DC. Based on the antiviral drug used, patients were categorised into the TMF group and the TAF group. Virological and serological responses, hepatic and renal functions and blood lipid changes in both groups were evaluated during 48 weeks of treatment. A total of 98 patients were enrolled, 45 in the TMF group and 53 in the TAF group. At 48 weeks of treatment, the proportions of patients who achieved complete virological response (CVR) were 85.7% and 90.7%, respectively (p = 0.791). Improvement of at least 2 points in Child-Turcotte-Pugh scores was observed in 64.3% versus 79.1% (p = 0.169) of the patients. There were no significant changes in serum creatinine, estimated glomerular filtration rate or total cholesterol from baseline to week 48 between the two groups. Cystatin C remained stable in the TMF group but increased over time in the TAF group (p < 0.001). Low-density lipoprotein cholesterol remained stable in the TMF group but increased significantly in the TAF group at week 48 (p = 0.015). These results suggest that both TMF and TAF can rapidly suppress HBV replication, improve hepatic function and have no negative effects on renal function among patients with HBV-DC. Regarding lipid metabolism, both showed a better safety, while regular monitoring of blood lipid levels is recommended.

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来源期刊
Journal of Viral Hepatitis
Journal of Viral Hepatitis 医学-病毒学
CiteScore
6.00
自引率
8.00%
发文量
138
审稿时长
1.5 months
期刊介绍: The Journal of Viral Hepatitis publishes reviews, original work (full papers) and short, rapid communications in the area of viral hepatitis. It solicits these articles from epidemiologists, clinicians, pathologists, virologists and specialists in transfusion medicine working in the field, thereby bringing together in a single journal the important issues in this expanding speciality. The Journal of Viral Hepatitis is a monthly journal, publishing reviews, original work (full papers) and short rapid communications in the area of viral hepatitis. It brings together in a single journal important issues in this rapidly expanding speciality including articles from: virologists; epidemiologists; clinicians; pathologists; specialists in transfusion medicine.
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