利用仪器和结晶技术对舍曲林进行对映体分离的策略：质量控制中的一个重要问题。

IF 1.8 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Biomedical Chromatography Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI:10.1002/bmc.6031

Raha Kaviani, Abolghasem Jouyban, Mahsa Javan, Behrouz Seyfinejad, Ali Shayanfar

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引用次数: 0

摘要

手性活性药物成分（API）的对映体通常表现出不同的物理化学、药效学和生物学特性。因此，对映体分离成为药物开发的一个关键环节。舍曲林是处方量最大的抗抑郁药物之一，需要从其手性杂质中进行纯化，这对其质量控制是非常重要的。本视角重点介绍了目前在舍曲林手性杂质的分离和定量方面已取得的研究成果，重点是基于仪器和结晶的技术。

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Enantioseparation strategies for sertraline by instrumental and crystallization-based techniques: An important issue in quality control.

Enantiomers of a chiral active pharmaceutical ingredient (API) often exhibit different physicochemical, pharmacokinetic, and biological properties. Therefore, enantioseparation becomes a critical aspect of pharmaceutical development. Sertraline, one of the most widely prescribed antidepressant medications, requires purification from its chiral impurities, and this is recommended and essential for its quality control. This perspective highlights the current established research on the separation and quantification of sertraline's chiral impurities, with a focus on instrumental and crystallization-based techniques.

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来源期刊

Biomedical Chromatography 生物-分析化学

CiteScore

3.60

自引率

5.60%

发文量

268

审稿时长

2.3 months

期刊介绍： Biomedical Chromatography is devoted to the publication of original papers on the applications of chromatography and allied techniques in the biological and medical sciences. Research papers and review articles cover the methods and techniques relevant to the separation, identification and determination of substances in biochemistry, biotechnology, molecular biology, cell biology, clinical chemistry, pharmacology and related disciplines. These include the analysis of body fluids, cells and tissues, purification of biologically important compounds, pharmaco-kinetics and sequencing methods using HPLC, GC, HPLC-MS, TLC, paper chromatography, affinity chromatography, gel filtration, electrophoresis and related techniques.