艾滋病暴露前预防中的后天梅毒:科学文献系统回顾。

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Nathália L Pedrosa, Patrícia M Pinheiro, Wildo N de Araújo
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引用次数: 0

摘要

本研究旨在系统回顾艾滋病暴露前预防(PrEP)治疗前和随访期间获得性梅毒的情况。我们分析了以获得性梅毒为结果对 PrEP 使用者进行研究的文章。合格标准是从美国国家医学图书馆(Pubmed)、拉丁美洲和加勒比海健康科学文献(Lilacs)、Embase 和 Scopus 数据库中检索到的研究,这些研究发表于 2012 年至 2023 年之间,语言为英语、西班牙语或葡萄牙语。我们采用纽卡斯尔-渥太华量表或科克伦量表对所选研究进行了描述性综合和质量分析。我们还使用随机效应模型对 PrEP 前和随访期间的梅毒率进行了汇总估算。共找到 4412 项研究,其中 35 项被选中,全部为英文研究,几乎全部质量较高或令人满意。审查发现 PrEP 梅毒感染率为 6.0%。三项研究的总结估计,在 PrEP 期间感染梅毒的风险增加了 2.34 倍,发病率为 8.89 例/100 人-年。由于研究的异质性,这些研究结果值得警惕。与 HIV 阳性者相比,PrEP 使用者的梅毒发病率可能更高,尤其是在 33-38 岁的人群中,而年龄≥ 35 岁、男男性行为者身份、既往性传播感染以及较长的 PrEP 持续时间(每 6 个月)等因素都与梅毒有关。未来的研究应进一步调查这些导致梅毒风险增加的 PrEP 相关因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acquired syphilis in the context of pre-exposure prophylaxis for HIV: a systematic review of the scientific literature.

The aim of this study was systematically review the acquired syphilis before and during follow-up of pre-exposure prophylaxis (PrEP) for HIV. We analyzed articles that studied PrEP users with the outcome of acquired syphilis. The eligibility criteria were studies retrieved from the United States National Library of Medicine (Pubmed), Latin American and Caribbean Health Sciences Literature (Lilacs), Embase and Scopus databases, published between 2012 and 2023, in English, Spanish or Portuguese. We performed the descriptive synthesis and quality analysis of selected studies using the Newcastle Ottawa scale or Cochrane scale. We also used random-effects models to generate pooled rate estimates for syphilis before PrEP and during follow-up. A total of 4412 studies were found and 35 were selected, all in English, and almost all with high or satisfactory quality. The review found a PrEP syphilis rate of 6.0%. A summary of three studies estimated a 2.34-fold increased risk of syphilis acquisition during PrEP, with an incidence rate of 8.89 cases/100 person-years. These findings warrant caution due to study heterogeneity. Compared to HIV-positive individuals, PrEP users exhibit potentially higher syphilis rates, particularly among those aged 33-38 years, and factors such as age ≥ 35 years, MSM status, prior sexually-transmitted infections, and longer PrEP duration (every 6 months) are associated. Future research should further investigate these PrEP-related factors contributing to heightened syphilis risk.

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来源期刊
AIDS reviews
AIDS reviews 医学-传染病学
CiteScore
3.40
自引率
4.50%
发文量
41
审稿时长
>12 weeks
期刊介绍: AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.
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